Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns.

IF 3.3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Metabolomics Pub Date : 2025-01-25 DOI:10.1007/s11306-024-02219-7

Jagadeesh Puvvula, Lucie C Song, Klaudia J Zalewska, Ariel Alexander, Kathrine E Manz, Joseph M Braun, Kurt D Pennell, Emily A DeFranco, Shuk-Mei Ho, Yuet-Kin Leung, Shouxiong Huang, Ann M Vuong, Stephani S Kim, Zana Percy, Priyanka Bhashyam, Raymund Lee, Dean P Jones, Vilinh Tran, Dasom V Kim, Antonia M Calafat, Julianne C Botelho, Aimin Chen

{"title":"Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns.","authors":"Jagadeesh Puvvula, Lucie C Song, Klaudia J Zalewska, Ariel Alexander, Kathrine E Manz, Joseph M Braun, Kurt D Pennell, Emily A DeFranco, Shuk-Mei Ho, Yuet-Kin Leung, Shouxiong Huang, Ann M Vuong, Stephani S Kim, Zana Percy, Priyanka Bhashyam, Raymund Lee, Dean P Jones, Vilinh Tran, Dasom V Kim, Antonia M Calafat, Julianne C Botelho, Aimin Chen","doi":"10.1007/s11306-024-02219-7","DOIUrl":null,"url":null,"abstract":"Background: Gestational exposure to non-persistent endocrine-disrupting chemicals (EDCs) may be associated with adverse pregnancy outcomes. While many EDCs affect the endocrine system, their effects on endocrine-related metabolic pathways remain unclear. This study aims to explore the global metabolome changes associated with EDC biomarkers at delivery.Methods: This study included 75 pregnant individuals who delivered at the University of Cincinnati Hospital from 2014 to 2017. We measured maternal urinary biomarkers of paraben/phenol (12), phthalate (13), and phthalate replacements (4) from the samples collected during the delivery visit. Global serum metabolome profiles were analyzed from maternal blood (n = 72) and newborn (n = 63) cord blood samples collected at delivery. Fifteen of the 29 urinary biomarkers were excluded due to low detection frequency or potential exposures during hospital stay. We assessed metabolome-wide associations between 14 maternal urinary biomarkers and maternal/newborn metabolome profiles. Additionally, performed enrichment analysis to identify potential alterations in metabolic pathways.Results: We observed metabolome-wide associations between maternal urinary concentrations of phthalate metabolites (mono-isobutyl phthalate), phthalate replacements (mono-2-ethyl-5-carboxypentyl terephthalate, mono-2-ethyl-5-hydroxyhexyl terephthalate) and phenols (bisphenol-A, bisphenol-S) and maternal serum metabolome, using q-value < 0.2 as a threshold. Additionally, associations of phthalate metabolites (mono-n-butyl phthalate, monobenzyl phthalate) and phenols (2,5-dichlorophenol, BPA) with the newborn metabolome were noted. Enrichment analyses revealed associations (p-gamma < 0.05) with amino acid, carbohydrate, lipid, glycan, vitamin, and other cofactor metabolism pathways.Conclusion: Maternal paraben, phenol, phthalate, and phthalate replacement biomarker concentrations at delivery were associated with maternal and newborn serum global metabolome.","PeriodicalId":18506,"journal":{"name":"Metabolomics","volume":"21 1","pages":"20"},"PeriodicalIF":3.3000,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762426/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Metabolomics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11306-024-02219-7","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Gestational exposure to non-persistent endocrine-disrupting chemicals (EDCs) may be associated with adverse pregnancy outcomes. While many EDCs affect the endocrine system, their effects on endocrine-related metabolic pathways remain unclear. This study aims to explore the global metabolome changes associated with EDC biomarkers at delivery.

Methods: This study included 75 pregnant individuals who delivered at the University of Cincinnati Hospital from 2014 to 2017. We measured maternal urinary biomarkers of paraben/phenol (12), phthalate (13), and phthalate replacements (4) from the samples collected during the delivery visit. Global serum metabolome profiles were analyzed from maternal blood (n = 72) and newborn (n = 63) cord blood samples collected at delivery. Fifteen of the 29 urinary biomarkers were excluded due to low detection frequency or potential exposures during hospital stay. We assessed metabolome-wide associations between 14 maternal urinary biomarkers and maternal/newborn metabolome profiles. Additionally, performed enrichment analysis to identify potential alterations in metabolic pathways.

Results: We observed metabolome-wide associations between maternal urinary concentrations of phthalate metabolites (mono-isobutyl phthalate), phthalate replacements (mono-2-ethyl-5-carboxypentyl terephthalate, mono-2-ethyl-5-hydroxyhexyl terephthalate) and phenols (bisphenol-A, bisphenol-S) and maternal serum metabolome, using q-value < 0.2 as a threshold. Additionally, associations of phthalate metabolites (mono-n-butyl phthalate, monobenzyl phthalate) and phenols (2,5-dichlorophenol, BPA) with the newborn metabolome were noted. Enrichment analyses revealed associations (p-gamma < 0.05) with amino acid, carbohydrate, lipid, glycan, vitamin, and other cofactor metabolism pathways.

Conclusion: Maternal paraben, phenol, phthalate, and phthalate replacement biomarker concentrations at delivery were associated with maternal and newborn serum global metabolome.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

孕妇和新生儿中与内分泌干扰物质相关的全球代谢组学改变。

背景：妊娠期暴露于非持久性内分泌干扰化学物质（EDCs）可能与不良妊娠结局有关。虽然许多EDCs影响内分泌系统，但它们对内分泌相关代谢途径的影响尚不清楚。本研究旨在探讨分娩时与EDC生物标志物相关的全球代谢组变化。方法：本研究纳入了2014年至2017年在辛辛那提大学医院分娩的75名孕妇。我们测量了产妇尿液中对羟基苯甲酸酯/苯酚（12）、邻苯二甲酸酯（13）和邻苯二甲酸酯替代品(4)的生物标志物。对分娩时采集的母体血液（n = 72）和新生儿脐带血（n = 63）进行全球血清代谢组分析。29项尿液生物标志物中有15项因检测频率低或住院期间可能暴露而被排除。我们评估了14种母体尿液生物标志物与母体/新生儿代谢组谱之间的全代谢组关联。此外，进行富集分析以确定代谢途径的潜在改变。结果：我们观察了母体尿液中邻苯二甲酸代谢物（邻苯二甲酸单异丁基）、邻苯二甲酸代谢物（邻苯二甲酸单2-乙基-5-羧基-5-羟基己基对苯二甲酸单2-乙基-5-羟基己基对苯二甲酸单2-乙基-5-羟基己基对苯二甲酸）和酚类（双酚a、双酚s）浓度与母体血清代谢组之间的全代谢组相关性。分娩时产妇对羟基苯甲酸酯、苯酚、邻苯二甲酸酯和邻苯二甲酸酯替代生物标志物浓度与产妇和新生儿血清总代谢组相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Metabolomics 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.80%

发文量

审稿时长

2 months

期刊介绍： Metabolomics publishes current research regarding the development of technology platforms for metabolomics. This includes, but is not limited to: metabolomic applications within man, including pre-clinical and clinical pharmacometabolomics for precision medicine metabolic profiling and fingerprinting metabolite target analysis metabolomic applications within animals, plants and microbes transcriptomics and proteomics in systems biology Metabolomics is an indispensable platform for researchers using new post-genomics approaches, to discover networks and interactions between metabolites, pharmaceuticals, SNPs, proteins and more. Its articles go beyond the genome and metabolome, by including original clinical study material together with big data from new emerging technologies.