Chronic Endometritis and Antimicrobial Resistance: Towards a Multidrug-Resistant Endometritis? An Expert Opinion.

IF 4.2 2区 生物学 Q2 MICROBIOLOGY Microorganisms Pub Date : 2025-01-17 DOI:10.3390/microorganisms13010197
Francesco Di Gennaro, Giacomo Guido, Luisa Frallonardo, Laura Pennazzi, Miriana Bevilacqua, Pietro Locantore, Amerigo Vitagliano, Annalisa Saracino, Ettore Cicinelli
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Abstract

Chronic endometritis (CE) is a persistent inflammatory condition of the endometrium characterized by abnormal infiltration of plasma cells into the endometrial stroma. Frequently associated with repeated implantation failure, recurrent pregnancy loss, and infertility, CE significantly impacts women's health, contributing to conditions such as abnormal uterine bleeding and endometriosis. Treatment typically involves antibiotic therapy; however, the efficacy of these treatments is increasingly compromised by the rise of antimicrobial resistance (AMR). This paper examines the critical links between AMR and CE, proposing strategies to enhance clinical management and optimize treatment outcomes.

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慢性子宫内膜炎与抗菌素耐药性:迈向多药耐药子宫内膜炎?专家意见。
慢性子宫内膜炎(CE)是一种持续的子宫内膜炎症,其特征是浆细胞异常浸润到子宫内膜基质中。CE通常与反复着床失败、反复妊娠流产和不孕有关,严重影响妇女健康,导致子宫异常出血和子宫内膜异位症等疾病。治疗通常包括抗生素治疗;然而,由于抗菌素耐药性(AMR)的上升,这些治疗的效果日益受到损害。本文探讨了AMR与CE之间的关键联系,并提出了加强临床管理和优化治疗结果的策略。
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来源期刊
Microorganisms
Microorganisms Medicine-Microbiology (medical)
CiteScore
7.40
自引率
6.70%
发文量
2168
审稿时长
20.03 days
期刊介绍: Microorganisms (ISSN 2076-2607) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to prokaryotic and eukaryotic microorganisms, viruses and prions. It publishes reviews, research papers and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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