Metabolomic Profiling Reveals Potential Biomarkers and Prominent Features in HIV/AIDS Patients Co-Infected with SARS-CoV-2.

IF 4.2 2区生物学 Q2 MICROBIOLOGY Microorganisms Pub Date : 2025-01-13 DOI:10.3390/microorganisms13010144

Xuan Yan, Xinyu Zhang, Wei Song, Tangkai Qi, Zhenyan Wang, Yang Tang, Jianjun Sun, Shuibao Xu, Junyang Yang, Jiangrong Wang, Jun Chen, Renfang Zhang, Li Liu, Yinzhong Shen

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Abstract

The underlying mechanisms and diagnostic biomarkers for the progress of COVID-19 in HIV patients have not been fully elucidated. In this study, the aim is to analyze the metabolomic profiles of HIV/AIDS patients co-infected with SARS-CoV-2 and to identify biomarkers indicative of co-infection. In this study, we conducted a retrospective cohort analysis of peripheral blood samples collected from 30 HIV/AIDS patients co-infected with SARS-CoV-2 (pc group) and 30 patients without SARS-CoV-2 (nc group). In this study, through non-targeted metabolomics and lipidomics analysis, 77 differential metabolites were identified in the plasma of patients co-infected with HIV and SARS-CoV-2 compared to the nc group, with vitamin K1 emerging as a significant feature. Moreover, the plasma of the pc group showed disturbances in lipid metabolism, with elevated triglycerides (TG) and phosphatidylcholine (PC) and decreased phosphatidylglycerol (PG) compared to the control group. Vitamin K1 may be a biomarker for SARS-CoV-2 in HIV/AIDS patients, and changes in the levels of TG, PC, and PG molecules appear to be the main features following HIV co-infection with COVID-19. The emphasis in our study is on the power of using comprehensive metabolomics (lipidomics) approaches to identify metabolic biomarkers and potential mechanisms of COVID-19 in HIV/AIDS patients.

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代谢组学分析揭示了合并SARS-CoV-2的HIV/AIDS患者的潜在生物标志物和突出特征

COVID-19在HIV患者中进展的潜在机制和诊断生物标志物尚未完全阐明。在本研究中，目的是分析合并感染SARS-CoV-2的HIV/AIDS患者的代谢组学特征，并确定指示合并感染的生物标志物。本研究对30例合并SARS-CoV-2的HIV/AIDS患者（pc组）和30例未合并SARS-CoV-2的患者（nc组）的外周血样本进行了回顾性队列分析。在本研究中，通过非靶向代谢组学和脂质组学分析，与nc组相比，HIV和SARS-CoV-2合并感染患者的血浆中鉴定出77种差异代谢物，其中维生素K1是一个显著特征。此外，与对照组相比，pc组的血浆脂质代谢出现紊乱，甘油三酯（TG）和磷脂酰胆碱（pc）升高，磷脂酰甘油（PG）降低。维生素K1可能是HIV/AIDS患者SARS-CoV-2的生物标志物，而TG、PC和PG分子水平的变化似乎是HIV合并COVID-19后的主要特征。我们研究的重点是利用综合代谢组学（脂质组学）方法识别HIV/AIDS患者中COVID-19的代谢生物标志物和潜在机制的力量。

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来源期刊

Microorganisms Medicine-Microbiology (medical)

CiteScore

7.40

自引率

6.70%

发文量

2168

审稿时长

20.03 days

期刊介绍： Microorganisms (ISSN 2076-2607) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to prokaryotic and eukaryotic microorganisms, viruses and prions. It publishes reviews, research papers and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.