{"title":"Platelet extracellular vesicles-loaded hydrogel bandages for personalized wound care.","authors":"Sabine Szunerits, Er-Yuan Chuang, Jen-Chang Yang, Rabah Boukherroub, Thierry Burnouf","doi":"10.1016/j.tibtech.2024.12.010","DOIUrl":null,"url":null,"abstract":"<p><p>Autologous or allogeneic platelet-derived extracellular vesicles (pEVs) show potential in enhancing tissue recovery and healing chronic wounds. pEVs promote neovascularization and cell migration while reducing inflammation, oxidative stress, and scarring. However, their efficacy in clinical settings is challenged by their susceptibility to washout by wound exudate. Hydrogel-based bandages are effective carriers that stabilize pEVs for optimal personalized wound care. These bandages can be tailored for easy removal to minimize damage to regenerated tissue and can incorporate antibacterial or moisture-retaining properties. Furthermore, the possibility of integrating sensors in the wound bed will enable a theragnostic approach to healing. This review explores advancements in pEV-loaded hydrogels and their potential for personalized clinical applications.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":" ","pages":""},"PeriodicalIF":14.3000,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1016/j.tibtech.2024.12.010","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Autologous or allogeneic platelet-derived extracellular vesicles (pEVs) show potential in enhancing tissue recovery and healing chronic wounds. pEVs promote neovascularization and cell migration while reducing inflammation, oxidative stress, and scarring. However, their efficacy in clinical settings is challenged by their susceptibility to washout by wound exudate. Hydrogel-based bandages are effective carriers that stabilize pEVs for optimal personalized wound care. These bandages can be tailored for easy removal to minimize damage to regenerated tissue and can incorporate antibacterial or moisture-retaining properties. Furthermore, the possibility of integrating sensors in the wound bed will enable a theragnostic approach to healing. This review explores advancements in pEV-loaded hydrogels and their potential for personalized clinical applications.
期刊介绍：
Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems.
The major themes that TIBTECH is interested in include:
Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering)
Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology)
Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics)
Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery)
Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).
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