Jiqiang Li , Weiming Wang , Zipeng Lin , Zhenyu Liu , Ruilin Zhang , Runwen Li , Jie Zhang , Youkun Zheng , Dalian Qin , Ya Wu , Yong Liu
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引用次数: 0
Abstract
Vinculin, a crucial adhesion plaque protein, plays a significant role in cell morphology and tissue development. Dysregulation of focal adhesion proteins has been linked to numerous diseases, including cardiovascular conditions, gastrointestinal disorders, and cancer. Recent studies increasingly highlight vinculin's involvement in the progression of these diseases; however, a comprehensive review remains lacking. Therefore, an in-depth and timely review is essential to consolidate the latest findings on vinculin's role in disease mechanisms. This study aims to examine how vinculin coordinates a complex network of signaling pathways across various pathological contexts.
期刊介绍：
Progress in Biophysics & Molecular Biology is an international review journal and covers the ground between the physical and biological sciences since its launch in 1950. It indicates to the physicist the great variety of unsolved problems awaiting attention in biology and medicine. The biologist and biochemist will find that this journal presents new and stimulating ideas and novel approaches to studying and influencing structural and functional properties of the living organism. This journal will be of particular interest to biophysicists, biologists, biochemists, cell physiologists, systems biologists, and molecular biologists.
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