Hospital discharges (MBDS) for Takotsubo syndrome in Spain. Regional differences (2008-2021).

Abstract

Background and objectives: Takotsubo syndrome (TTS) is an infrequent cause of acute coronary syndrome much better diagnosed in recent years. This study sought to assess the clinical profile of patients admitted with TTS in Spain and to elucidate potential regional differences in admissions and in-hospital mortality between the years 2008 and 2021.

Methods: Retrospective observational study of patients admitted to acute general hospitals of the Spanish National Health System with a main or secondary diagnosis of STT, using the minimum basic data set.

Results: A total of 12,952 hospitalization for TTS were identified. The number of hospital admissions increased exponentially from 210 in the year 2008 to 1918 in 2021. Most patients (79.1%) were women and mean age was 72.0 ± 12.5 years (72.5 ± 12.2 in female; 69.9 ± 13.4 in men; p < 0.001). Associated comorbidities were frequent (44.9% arterial hypertension, 31.2% heart failure) and differed in men and women. Overall, crude in-hospital mortality was 7%. Notably, admission and in-hospital mortality rates, adjusted by age and gender, were different among the different autonomous communities.

Conclusions: TTS usually presents in elderly women with associated comorbidities and has a significant in-hospital mortality. Age and comorbidities differ between men and women. Relevant regional differences exist regarding admission and in-hospital mortality rates.