Advances in Electrochemical Nitrite Reduction toward Nitric Oxide Synthesis for Biomedical Applications

IF 9.6 2区医学 Q1 ENGINEERING, BIOMEDICAL Advanced Healthcare Materials Pub Date : 2025-01-26 DOI:10.1002/adhm.202403468

Xun He, Chang Zou, Limei Zhang, Peilin Wu, Yongchao Yao, Kai Dong, Yuchun Ren, Wenchuang (Walter) Hu, Yi Li, Han Luo, Binwu Ying, Fengming Luo, Xuping Sun

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Abstract

Nitric oxide (NO) is an essential molecule in biomedicine, recognized for its antibacterial properties, neuronal modulation, and use in inhalation therapies. The effectiveness of NO-based treatments relies on precise control of NO concentrations tailored to specific therapeutic needs. Electrochemical generation of NO (E-NOgen) via nitrite (NO₂^–) reduction offers a scalable and efficient route for controlled NO production, while also addressing environmental concerns by reducing NO₂^– pollution and maintaining nitrogen cycle balance. Recent developments in catalysts and E-NOgen devices have propelled NO₂^– conversion, enabling on-demand NO production. This review provides an overview of NO₂⁻ reduction pathways, with a focus on cutting-edge Fe/Cu-based E-NOgen catalysts, and explores the development of E-NOgen devices for biomedical use. Challenges and future directions for advancing E-NOgen technologies are also discussed.

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电化学亚硝酸盐还原合成生物医学用途一氧化氮的研究进展。

一氧化氮（NO）是生物医学中必不可少的分子，因其抗菌特性、神经元调节和吸入疗法而被认可。一氧化氮治疗的有效性依赖于对一氧化氮浓度的精确控制，以满足特定的治疗需求。通过亚硝酸盐（NO2 -）还原电化学生成NO （E-NOgen）为控制NO生产提供了一种可扩展和有效的途径，同时也通过减少NO2 -污染和维持氮循环平衡来解决环境问题。催化剂和E-NOgen设备的最新发展推动了NO2的转化，使按需生产NO成为可能。本文综述了NO2 -还原途径，重点介绍了Fe/ cu基E-NOgen催化剂，并探讨了生物医学用E-NOgen装置的发展。讨论了推进E-NOgen技术的挑战和未来方向。

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.