Advances in Electrochemical Nitrite Reduction toward Nitric Oxide Synthesis for Biomedical Applications.

IF 10 2区医学 Q1 ENGINEERING, BIOMEDICAL Advanced Healthcare Materials Pub Date : 2025-01-26 DOI:10.1002/adhm.202403468

Xun He, Chang Zou, Limei Zhang, Peilin Wu, Yongchao Yao, Kai Dong, Yuchun Ren, Wenchuang Walter Hu, Yi Li, Han Luo, Binwu Ying, Fengming Luo, Xuping Sun

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引用次数: 0

Abstract

Nitric oxide (NO) is an essential molecule in biomedicine, recognized for its antibacterial properties, neuronal modulation, and use in inhalation therapies. The effectiveness of NO-based treatments relies on precise control of NO concentrations tailored to specific therapeutic needs. Electrochemical generation of NO (E-NOgen) via nitrite (NO₂ ^-) reduction offers a scalable and efficient route for controlled NO production, while also addressing environmental concerns by reducing NO₂ ^- pollution and maintaining nitrogen cycle balance. Recent developments in catalysts and E-NOgen devices have propelled NO₂ ^- conversion, enabling on-demand NO production. This review provides an overview of NO₂ ^- reduction pathways, with a focus on cutting-edge Fe/Cu-based E-NOgen catalysts, and explores the development of E-NOgen devices for biomedical use. Challenges and future directions for advancing E-NOgen technologies are also discussed.

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.