Li Wang, Lu Fan, Anne M Filppula, Yu Wang, Feika Bian, Luoran Shang, Hongbo Zhang
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引用次数: 0
Abstract
Hydrogel-based patches have demonstrated their values in diabetic wounds repair, particularly those intelligent dressings with continuous repair promoting and monitoring capabilities. Here, we propose a type of dual physiological responsive structural color particles for wound repair. The particles are composed of a hyaluronic acid methacryloyl (HAMA)-sodium alginate (Alg) inverse opal scaffold, filled with oxidized dextran (ODex)/quaternized chitosan (QCS) hydrogel. The photo-polymerized HAMA and ionically cross-linked Ca-Alg constitute to the dual-network hydrogel with stable structural color. Furthermore, the ODex/QCS hydrogel, combined with glucose oxidase (GOX), exhibits pH/glucose dual responsiveness. Moreover, antimmicrobial peptide (AMP) plus vascular endothelial growth factor (VEGF) are comprised within the GOX-doped ODex/QCS hydrogel. In the high-glucose wound environment, GOX catalyzes glucose to generate acidic products, triggering rapid release of AMP and VEGF. Importantly, this process also leads to structural color changes of the particles, offering significant potential for wound monitoring. It has been demonstrated that such particles greatly promote the healing progress of diabetic wound in vivo. These results indicate that the present dual responsive particles would find valuable applications in diabetic wounds repair and the associated areas.
IF 18.9 1区 医学Bioactive MaterialsPub Date : 2022-09-01DOI: 10.1016/j.bioactmat.2021.11.037
Canwen Chen , Yu Wang , Han Zhang , Hui Zhang , Weiliang Dong , Weijian Sun , Yuanjin Zhao
来源期刊
Bioactive MaterialsBiochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
28.00
自引率
6.30%
发文量
436
审稿时长
20 days
期刊介绍:
Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms.
The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms.
The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials:
Bioactive metals and alloys
Bioactive inorganics: ceramics, glasses, and carbon-based materials
Bioactive polymers and gels
Bioactive materials derived from natural sources
Bioactive composites
These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.