Evaluation of the Role of PnuC Gene in Enhancing Nicotinamide Mononucleotide Synthesis

IF 2.7 4区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biotechnology and applied biochemistry Pub Date : 2025-01-26 DOI:10.1002/bab.2713

Giang Thi Thu Vo, Khang Khoa Hoang Nguyen, Beom Soo Kim

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Abstract

The PnuC gene plays a crucial role in the complex processes related to the absorption and synthesis of the nicotinamide mononucleotide (NMN) precursor. NMN, a nicotinamide adenine dinucleotide (NAD⁺) precursor, is important for cellular energy metabolism, DNA repair, and antiaging. This study focuses on elucidating the precursor absorption mechanism and the specific function of the PnuC gene in encoding membrane transport proteins, as well as its impact on the regulation and dynamics of NMN within the cell. This understanding aims to provide insights into its potential effects on metabolic balance, illustrated through two NAD⁺ biosynthesis pathways based on renewable and readily available cytoplasmic resources, assessing the potential of PnuC gene expression in clarifying complex interactions within regulation mechanisms. Enhanced expression analysis of the PnuC gene has initiated discussions on its potential applications in treating aging-related diseases and dysfunctions, contributing to cellular health maintenance.

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PnuC基因在促进烟酰胺单核苷酸合成中的作用评价。

PnuC基因在烟酰胺单核苷酸（NMN）前体的吸收和合成的复杂过程中起着至关重要的作用。NMN是一种烟酰胺腺嘌呤二核苷酸（NAD+）前体，对细胞能量代谢、DNA修复和抗衰老具有重要作用。本研究重点阐明PnuC基因在编码膜转运蛋白中的前体吸收机制和具体功能，以及其对细胞内NMN调控和动力学的影响。这一理解旨在通过基于可再生和可利用的细胞质资源的两种NAD+生物合成途径来阐明其对代谢平衡的潜在影响，评估PnuC基因表达在阐明调控机制内复杂相互作用方面的潜力。PnuC基因的增强表达分析已经开始讨论其在治疗衰老相关疾病和功能障碍方面的潜在应用，有助于细胞健康的维持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biotechnology and applied biochemistry 工程技术-生化与分子生物学

CiteScore

6.00

自引率

7.10%

发文量

117

审稿时长

3 months

期刊介绍： Published since 1979, Biotechnology and Applied Biochemistry is dedicated to the rapid publication of high quality, significant research at the interface between life sciences and their technological exploitation. The Editors will consider papers for publication based on their novelty and impact as well as their contribution to the advancement of medical biotechnology and industrial biotechnology, covering cutting-edge research in synthetic biology, systems biology, metabolic engineering, bioengineering, biomaterials, biosensing, and nano-biotechnology.