Exosomes in Oral Diseases: Mechanisms and Therapeutic Applications.

IF 5.1 2区医学 Q1 CHEMISTRY, MEDICINAL Drug Design, Development and Therapy Pub Date : 2025-01-22 eCollection Date: 2025-01-01 DOI:10.2147/DDDT.S505355

Qiandai Miao, Shaoqing Li, Weijia Lyu, Jianxia Zhang, Yan Han

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Abstract

Exosomes, small extracellular vesicles secreted by various cells, play crucial roles in the pathogenesis and treatment of oral diseases. Recent studies have highlighted their involvement in orthodontics, periodontitis, oral squamous cell carcinoma (OSCC), and hand, foot, and mouth disease (HFMD). Exosomes have a positive effect on the inflammatory environment of the oral cavity, remodeling and regeneration of oral tissues, and offer promising therapeutic options for bone and periodontal tissue restoration. In OSCC tumor-derived exosomes promote cancer progression through cell proliferation, migration, invasion, and angiogenesis, and serve as potential biomarkers for early diagnosis and prognosis. Additionally, engineered exosomes constructed specifically based on exosome properties hold great promise for targeted drug delivery and regenerative therapies such as bone regeneration in orthodontics and periodontal healing. With continued research, exosomes hold great potential for improving diagnosis and treatment in oral diseases, advancing personalized and regenerative therapies.

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口腔疾病中的外泌体：机制和治疗应用。

外泌体是由多种细胞分泌的细胞外小泡，在口腔疾病的发病和治疗中起着至关重要的作用。最近的研究强调了它们在正畸、牙周炎、口腔鳞状细胞癌（OSCC）和手足口病（HFMD）中的作用。外泌体对口腔炎症环境、口腔组织重塑和再生具有积极作用，为骨和牙周组织修复提供了有希望的治疗选择。在OSCC中，肿瘤源性外泌体通过细胞增殖、迁移、侵袭和血管生成促进癌症进展，并作为早期诊断和预后的潜在生物标志物。此外，基于外泌体特性构建的工程外泌体在靶向药物输送和再生治疗（如正畸和牙周愈合中的骨再生）方面具有很大的前景。随着研究的不断深入，外泌体在改善口腔疾病的诊断和治疗、推进个性化和再生治疗方面具有巨大的潜力。

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来源期刊

Drug Design, Development and Therapy CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY

CiteScore

9.00

自引率

0.00%

发文量

382

审稿时长

>12 weeks

期刊介绍： Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications. The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas. Specific topics covered by the journal include: Drug target identification and validation Phenotypic screening and target deconvolution Biochemical analyses of drug targets and their pathways New methods or relevant applications in molecular/drug design and computer-aided drug discovery* Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes) Structural or molecular biological studies elucidating molecular recognition processes Fragment-based drug discovery Pharmaceutical/red biotechnology Isolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products** Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing) Preclinical development studies Translational animal models Mechanisms of action and signalling pathways Toxicology Gene therapy, cell therapy and immunotherapy Personalized medicine and pharmacogenomics Clinical drug evaluation Patient safety and sustained use of medicines.