Phytosomes-Unraveling the Unique Properties of Plant-Derived Nanotechnological Drug Delivery Systems: A Review.

IF 3.5 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Current medicinal chemistry Pub Date : 2025-01-01 DOI:10.2174/0109298673319759250116104648
Fatma Sezer Senol Deniz, Fatma Nur Tugcu Demiroz, Onur Kenan Ulutas, Ilkay Erdogan Orhan
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Abstract

Phytosomes are innovative compounds that enhance the bioavailability of plant-derived compounds, making them more effective in pharmaceuticals and nutraceuticals. By improving cellular absorption, phytosomes allow lower doses of plant extracts to achieve therapeutic effects, which may reduce both cost and the risk of potential side effects. The incorporation of phospholipids in phytosomes not only stabilizes the active compounds but also protects them from degradation in the gastrointestinal tract, potentially increasing their shelf life and efficacy. Despite their promise, more clinical trials are essential to fully validate the safety and therapeutic benefits of phytosomes. Ongoing research and developments may lead to a better understanding of their mechanisms of action and safety profiles and broaden their application in medicine.

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植物源纳米给药系统的独特性质:综述。
磷脂小体是一种创新的化合物,可以提高植物源性化合物的生物利用度,使其在药物和保健品中更有效。通过改善细胞吸收,磷脂小体允许较低剂量的植物提取物达到治疗效果,这可能降低成本和潜在副作用的风险。磷脂在磷脂体中的掺入不仅稳定了活性化合物,而且还保护它们在胃肠道中不被降解,潜在地增加了它们的保质期和功效。尽管他们的承诺,更多的临床试验是必要的,以充分验证磷脂体的安全性和治疗效益。正在进行的研究和发展可能会使人们更好地了解它们的作用机制和安全性,并扩大它们在医学上的应用。
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来源期刊
Current medicinal chemistry
Current medicinal chemistry 医学-生化与分子生物学
CiteScore
8.60
自引率
2.40%
发文量
468
审稿时长
3 months
期刊介绍: Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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