Correlation between weight-adjusted waist index and coronary heart disease: NHANES 1999-2020.

IF 2.8 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Frontiers in Cardiovascular Medicine Pub Date : 2025-01-10 eCollection Date: 2024-01-01 DOI:10.3389/fcvm.2024.1445802

Yan Liu, Shougang Sun, Qi Zou, Ting Tao, Dian Li, Guodong Han, Zhiliang Wei

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Abstract

Background: The weight adjusted waist index (WWI) represents a novel indicator for assessing central obesity. The objective of this study is to investigate the association between WWI and coronary heart disease (CHD).

Method: The data of 44,528 participants in total were gathered from NHANES database from 1999 to 2020. WWI is calculated as the waist circumference (WC, cm) divided by the square root of the body weight (kg), and CHD was determined based on participants' self-reports. The association between WWI and CHD was examined using multiple logistic regression analysis, restrictive cubic spline (RCS), receiver operating characteristic (ROC) curve, mediation analysis, subgroup and interaction analyses.

Result: This was a cross-sectional investigation. A total of 44,528 participants were included [50.23% male; mean WWI 10.89 (0.01) cm/√kg]. The multivariate logistic regression analysis revealed that in three models, one-standard-deviation increment in WWI was associated with an increased probability of CHD occurrence by 2.39 (2.22,2.57),1.47 (1.32,1.65), and 1.15 (1.00,1.32) times, respectively. Additionally, RCS analysis indicated a linear relationship between WWI and CHD. and the ROC analysis results showed that the discriminatory power of WWI for CHD was superior to that of body mass index (BMI) and WC. Glycated hemoglobin (HbA1c) partially mediated the relationship between WWI and CHD. Subgroup and interaction analyses confirmed that age, systolic blood pressure, and diabetes status had a significant impact on the association between WWI and CHD (P for interaction <0.05).

Conclusion: The level of WWI has been demonstrated to be associated with an increased risk of CHD. Specifically, as WWI increases, the risk of CHD becomes higher. On this basis, it is hypothesized that WWI may potentially serve as an independent risk factor for CAD, thereby highlighting the substantial value of WWI in the identification and management of CHD.

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体重调整腰围指数与冠心病的相关性：NHANES 1999-2020。

背景：体重调整腰围指数（WWI）是评估中心性肥胖的新指标。本研究旨在探讨第一次世界大战与冠心病（CHD）的关系。方法：从1999年至2020年NHANES数据库中收集44,528名参与者的数据。WWI的计算方法为腰围（WC, cm）除以体重（kg）的平方根，CHD是根据参与者的自我报告确定的。采用多元logistic回归分析、限制性三次样条（RCS）、受试者工作特征（ROC）曲线、中介分析、亚组分析和交互作用分析来检验一战与冠心病的相关性。结果：这是一项横断面调查。共纳入44,528名参与者[50.23%男性；一战平均10.89 (0.01)cm/√kg]。多因素logistic回归分析显示，WWI每增加1个标准差，冠心病发生概率分别增加2.39（2.22,2.57）倍、1.47（1.32,1.65）倍和1.15（1.00,1.32）倍。此外，RCS分析显示第一次世界大战与冠心病之间存在线性关系。ROC分析结果显示，WWI对冠心病的鉴别力优于体质指数（BMI）和WC。糖化血红蛋白（HbA1c）在WWI与冠心病的关系中起部分介导作用。亚组分析和相互作用分析证实，年龄、收缩压和糖尿病状态对WWI和冠心病之间的关系有显著影响（P为相互作用）。结论：WWI水平已被证明与冠心病风险增加有关。具体来说，随着第一次世界大战的增加，冠心病的风险变得更高。在此基础上，我们假设WWI可能是冠心病的一个独立危险因素，从而突出了WWI在冠心病的识别和管理中的重要价值。

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来源期刊

Frontiers in Cardiovascular Medicine Medicine-Cardiology and Cardiovascular Medicine

CiteScore

3.80

自引率

11.10%

发文量

3529

审稿时长

14 weeks

期刊介绍： Frontiers? Which frontiers? Where exactly are the frontiers of cardiovascular medicine? And who should be defining these frontiers? At Frontiers in Cardiovascular Medicine we believe it is worth being curious to foresee and explore beyond the current frontiers. In other words, we would like, through the articles published by our community journal Frontiers in Cardiovascular Medicine, to anticipate the future of cardiovascular medicine, and thus better prevent cardiovascular disorders and improve therapeutic options and outcomes of our patients.