Within-session habituation and salivary cortisol during exposure treatment in obsessive-compulsive disorder - A link and an influence of DHEA?

IF 2 4区医学 Q3 PSYCHIATRY Indian Journal of Psychiatry Pub Date : 2024-12-01 Epub Date: 2024-12-12 DOI:10.4103/indianjpsychiatry.indianjpsychiatry_566_24

Michael Kellner, Alexander Yassouridis, Christoph Muhtz, Klaus Wiedemann

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Abstract

Background: Glucocorticoids increase fear extinction in preclinical and human studies. Endogenous cortisol might influence who will benefit from exposure therapy in anxiety-spectrum disorders.

Methods: To investigate the impact of cortisol levels on within-session habituation of distress - a measure of success of exposure therapy - in obsessive-compulsive disorder (OCD) fifty-one OCD patients were studied during their stressful first cognitive-behavioral exposure therapy session with response prevention. Subjective units of distress, salivary cortisol, and salivary dehydroepiandrosterone (DHEA) were measured repeatedly before and during this afternoon session.

Results: No significant association of within-session habituation of distress and cortisol level during exposure was found. Calculating with the cortisol/DHEA ratio, similar results emerged.

Conclusion: Studies using endogenous diurnal fluctuation of cortisol and studies with administration of exogenous cortisol are needed to test whether glucocorticoids can augment exposure session outcome.

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强迫症暴露治疗期间的会话内习惯化和唾液皮质醇-脱氢表雄酮的联系和影响？

背景：糖皮质激素在临床前和人体研究中增加恐惧消退。内源性皮质醇可能会影响谁将受益于暴露治疗焦虑谱系障碍。方法：为了研究皮质醇水平对强迫症（OCD）患者在应激性第一次认知行为暴露治疗（反应预防）期间的痛苦习惯化（暴露治疗成功的一种衡量标准）的影响。主观痛苦单位、唾液皮质醇和唾液脱氢表雄酮（DHEA）在下午会议之前和期间反复测量。结果：暴露期间的应激习惯与皮质醇水平无显著关联。通过计算皮质醇/脱氢表雄酮的比例，得出了类似的结果。结论：需要使用内源性皮质醇的日波动和外源性皮质醇的研究来测试糖皮质激素是否可以增加暴露期的结果。

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来源期刊

Indian Journal of Psychiatry Medicine-Psychiatry and Mental Health

CiteScore

4.40

自引率

3.20%

发文量

130

审稿时长

34 weeks

期刊介绍： The Indian Journal of Psychiatry (ISSN 0019-5545), is an official publication of the Indian Psychiatric Society. It is published Bimonthly with one additional supplement (total 5 issues). The IJP publishes original work in all the fields of psychiatry. All papers are peer-reviewed before publication. The issues are published Bimonthly. An additional supplement is also published annually. Articles can be submitted online from www.journalonweb.com . The journal provides immediate free access to all the published articles. The journal does not charge the authors for submission, processing or publication of the articles.