Cortical hypometabolism as a predictor of intermittent theta burst stimulation response in treatment-resistant depression patients: An open-label study.

IF 2 4区医学 Q3 PSYCHIATRY Indian Journal of Psychiatry Pub Date : 2024-12-01 Epub Date: 2024-12-12 DOI:10.4103/indianjpsychiatry.indianjpsychiatry_161_24

Nidhisha Bajaj, Nand Kumar, Rakesh Kumar, Vaibhav Patil, Anshul Sharma

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Abstract

Background: Intermittent theta burst stimulation (iTBS) is an accepted and approved brain stimulation technique to treat patients with treatment-resistant depression.

Aim: Using neuroimaging, this open-label study aimed to predict the response by observing glucose metabolism with the help of 18-FDG PET scan.

Methods: A total of 25 treatment-resistant depression patients received 15 sessions of iTBS on the left dorsolateral prefrontal cortex. Two FDG-PET scans were done for all the patients. Fifty-six percent of patients responded to treatment with iTBS.

Results: We found that there was hypometabolism in left and right prefrontal lateral regions, left and right inferior parietal regions, and left prefrontal medial regions at baseline but no statistically significant difference in the metabolism between responders and nonresponders.

Conclusion: We did not find any statistically significant difference in the metabolism between responders and nonresponders in any brain regions at T0 as well as T1. Further large-scale studies are required.

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皮质低代谢作为治疗难治性抑郁症患者间歇性θ波爆发刺激反应的预测因子：一项开放标签研究。

背景：间歇性θ波爆发刺激（iTBS）是一种公认和批准的脑刺激技术，用于治疗难治性抑郁症患者。目的：利用神经影像学，本开放标签研究旨在通过18-FDG PET扫描观察糖代谢来预测反应。方法：共25例难治性抑郁症患者在左背外侧前额皮质接受15次iTBS治疗。所有患者均行2次FDG-PET扫描。56%的患者对iTBS治疗有反应。结果：我们发现在基线时左右额叶外侧区、左右下顶叶区和左额叶内侧区存在低代谢，但应答者和无应答者的代谢差异无统计学意义。结论：在T0和T1时，我们没有发现有反应者和无反应者在任何脑区的代谢有统计学差异。需要进一步的大规模研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Psychiatry Medicine-Psychiatry and Mental Health

CiteScore

4.40

自引率

3.20%

发文量

130

审稿时长

34 weeks

期刊介绍： The Indian Journal of Psychiatry (ISSN 0019-5545), is an official publication of the Indian Psychiatric Society. It is published Bimonthly with one additional supplement (total 5 issues). The IJP publishes original work in all the fields of psychiatry. All papers are peer-reviewed before publication. The issues are published Bimonthly. An additional supplement is also published annually. Articles can be submitted online from www.journalonweb.com . The journal provides immediate free access to all the published articles. The journal does not charge the authors for submission, processing or publication of the articles.