{"title":"Expression of PCED1A in Hepatocellular Carcinoma and Colorectal Cancer and Its Relationship with Immune Infiltration: Potential as a Diagnostic Marker","authors":"Meiling Wang, Qiqi Zhang, Jing Wang","doi":"10.1111/jgh.16890","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Hepatocellular carcinoma (HCC) and colorectal cancer (CRC) pose a significant threat to human health worldwide, characterized by intricate pathogenesis. A PC-esterase domain containing 1A (<i>PCED1A</i>) is a critical number of the <i>GDSL/SGNH</i> superfamily.</p>\n </section>\n \n <section>\n \n <h3> Aim</h3>\n \n <p>The aim of this study is to explore the diagnostic value of <i>PCED1A</i> in HCC and CRC and its relationship with immune infiltration.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The Cancer Genome Atlas (TCGA) database, Gene Expression Omnibus (GEO) database, the Cancer Cell Line Encyclopedia database (CCLE), and the Human Protein Atlas (HPA) were used to detect the expression of <i>PCED1A</i> in tissues and cells. Cibersoft, Timer, and Xcell were used to analyze the effect of <i>PCED1A</i> on immune cell infiltration. The relationship between <i>PCED1A</i> and the immune checkpoint was analyzed. The coexpression analysis of <i>PCED1A</i> was conducted using the LinkedOmics database.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p><i>PCED1A</i> was increased in HCC and CRC with poor prognosis. Immunohistochemistry demonstrated that <i>PCED1A</i> was highly expressed in HCC and CRC compared to corresponding normal tissues. <i>PCED1A</i> expression was related to poor overall survival (OS) and progression-free survival (PFS). High <i>PCED1A</i> expression was strongly associated with M2 macrophages, impacting HCC progression. Conversely, low <i>PCED1A</i> expression was closely related to Th2 cells in CRC. In addition, the checkpoint named <i>PDCD1</i> showed a good correlation with <i>PCED1A</i> high expression group in HCC and CRC. Lastly, the <i>PCED1A</i> and <i>ZNF</i> family showed a complex and intertwined relationship through coexpression analysis on the LinkedOmics database.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p><i>PCED1A</i>, related to tumor immune infiltration, is a promising diagnostic biomarker and a valuable therapeutic target for HCC and CRC.</p>\n </section>\n </div>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 4","pages":"873-883"},"PeriodicalIF":3.4000,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Gastroenterology and Hepatology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jgh.16890","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background
Hepatocellular carcinoma (HCC) and colorectal cancer (CRC) pose a significant threat to human health worldwide, characterized by intricate pathogenesis. A PC-esterase domain containing 1A (PCED1A) is a critical number of the GDSL/SGNH superfamily.
Aim
The aim of this study is to explore the diagnostic value of PCED1A in HCC and CRC and its relationship with immune infiltration.
Methods
The Cancer Genome Atlas (TCGA) database, Gene Expression Omnibus (GEO) database, the Cancer Cell Line Encyclopedia database (CCLE), and the Human Protein Atlas (HPA) were used to detect the expression of PCED1A in tissues and cells. Cibersoft, Timer, and Xcell were used to analyze the effect of PCED1A on immune cell infiltration. The relationship between PCED1A and the immune checkpoint was analyzed. The coexpression analysis of PCED1A was conducted using the LinkedOmics database.
Results
PCED1A was increased in HCC and CRC with poor prognosis. Immunohistochemistry demonstrated that PCED1A was highly expressed in HCC and CRC compared to corresponding normal tissues. PCED1A expression was related to poor overall survival (OS) and progression-free survival (PFS). High PCED1A expression was strongly associated with M2 macrophages, impacting HCC progression. Conversely, low PCED1A expression was closely related to Th2 cells in CRC. In addition, the checkpoint named PDCD1 showed a good correlation with PCED1A high expression group in HCC and CRC. Lastly, the PCED1A and ZNF family showed a complex and intertwined relationship through coexpression analysis on the LinkedOmics database.
Conclusion
PCED1A, related to tumor immune infiltration, is a promising diagnostic biomarker and a valuable therapeutic target for HCC and CRC.
背景：肝细胞癌（HCC）和结直肠癌（CRC）在全球范围内对人类健康构成重大威胁，其发病机制复杂。含有1A （PCED1A）的pc -酯酶结构域是GDSL/SGNH超家族的关键编号。目的：探讨PCED1A在HCC和CRC中的诊断价值及其与免疫浸润的关系。方法：利用Cancer Genome Atlas （TCGA）数据库、Gene Expression Omnibus （GEO）数据库、Cancer Cell Line Encyclopedia数据库（CCLE）和Human Protein Atlas （HPA）检测PCED1A在组织和细胞中的表达。采用Cibersoft、Timer、Xcell分析PCED1A对免疫细胞浸润的影响。分析了PCED1A与免疫检查点的关系。利用LinkedOmics数据库对PCED1A进行共表达分析。结果：PCED1A在预后较差的HCC和CRC中表达升高。免疫组织化学表明，与相应的正常组织相比，PCED1A在HCC和CRC中高表达。PCED1A表达与较差的总生存期（OS）和无进展生存期（PFS）相关。PCED1A高表达与M2巨噬细胞密切相关，影响HCC进展。相反，在结直肠癌中，低PCED1A表达与Th2细胞密切相关。此外，在HCC和CRC中，名为PDCD1的检查点与PCED1A高表达组有良好的相关性。最后，通过LinkedOmics数据库的共表达分析，PCED1A和ZNF家族表现出复杂而交织的关系。结论：PCED1A与肿瘤免疫浸润有关，是一种有前景的诊断性生物标志物，是HCC和CRC有价值的治疗靶点。
期刊介绍：
Journal of Gastroenterology and Hepatology is produced 12 times per year and publishes peer-reviewed original papers, reviews and editorials concerned with clinical practice and research in the fields of hepatology, gastroenterology and endoscopy. Papers cover the medical, radiological, pathological, biochemical, physiological and historical aspects of the subject areas. All submitted papers are reviewed by at least two referees expert in the field of the submitted paper.
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