The role of metabolites in the progression of osteoarthritis: Mechanisms and advances in therapy

IF 5.9 1区医学 Q1 ORTHOPEDICS Journal of Orthopaedic Translation Pub Date : 2025-01-01 Epub Date: 2025-01-07 DOI:10.1016/j.jot.2024.10.003

Xiaofeng Liu , Yongqiang Zheng , Hao Li , Yiyang Ma , Ruomu Cao , Zhikai Zheng , Yuchen Tian , Lin Du , Jinshan Zhang , Changqing Zhang , Junjie Gao

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Abstract

Osteoarthritis (OA) is a progressive degenerative disease affected by many factors, and there is currently no effective treatment. In recent years, the latest progress in metabolomics in OA research has revealed several metabolic pathways and new specific metabolites involved in OA. Metabolites play significant roles in the identification and management of OA. This review looks back on the development history of metabolomics and the progress of this technology in OA as well as its potential clinical applications. It summarizes the applications of metabolites in the field of OA and future research directions. This understanding will advance the identification of metabolic treatment goals for OA.

The translational potential of this article

The development of metabolomics offers possibilities for the treatment of OA. This article reviews the relationship between metabolites associated with chondrocytes and OA. Selectively altering these three metabolic pathways and their associated metabolites may hold great potential as new focal points for OA treatment.

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代谢物在骨关节炎进展中的作用：机制和治疗进展。

骨关节炎（OA）是一种受多种因素影响的进行性退行性疾病，目前尚无有效的治疗方法。近年来，代谢组学在OA研究中的最新进展揭示了OA参与的几种代谢途径和新的特异性代谢物。代谢物在OA的识别和管理中起着重要作用。本文综述了代谢组学的发展历史、代谢组学在OA中的研究进展及潜在的临床应用前景。总结了代谢物在OA领域的应用及未来的研究方向。这一认识将促进OA代谢治疗目标的确定。本文的翻译潜力：代谢组学的发展为OA的治疗提供了可能性。本文就软骨细胞相关代谢物与骨性关节炎的关系进行综述。选择性地改变这三种代谢途径及其相关代谢物可能具有巨大的潜力，成为OA治疗的新焦点。

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来源期刊

Journal of Orthopaedic Translation Medicine-Orthopedics and Sports Medicine

CiteScore

11.80

自引率

13.60%

发文量

审稿时长

29 days

期刊介绍： The Journal of Orthopaedic Translation (JOT) is the official peer-reviewed, open access journal of the Chinese Speaking Orthopaedic Society (CSOS) and the International Chinese Musculoskeletal Research Society (ICMRS). It is published quarterly, in January, April, July and October, by Elsevier.