Correlating the Optical Coherence Tomography Patterns and Biomarkers of Diabetic Macular Edema with Hemoglobin Level in Diabetic Kidney Disease.

Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-01-21 eCollection Date: 2025-01-01 DOI:10.2147/OPTH.S447826

Nikhil Gopalakrishnan, Shankar Prasad Nagaraju, Neenu Mariam George, Sulatha V Bhandary, Yogish S Kamath, Sushan Shankar Shetty, Soumya S Nair, Neetha I R Kuzhuppilly, Shailaja S

{"title":"Correlating the Optical Coherence Tomography Patterns and Biomarkers of Diabetic Macular Edema with Hemoglobin Level in Diabetic Kidney Disease.","authors":"Nikhil Gopalakrishnan, Shankar Prasad Nagaraju, Neenu Mariam George, Sulatha V Bhandary, Yogish S Kamath, Sushan Shankar Shetty, Soumya S Nair, Neetha I R Kuzhuppilly, Shailaja S","doi":"10.2147/OPTH.S447826","DOIUrl":null,"url":null,"abstract":"Purpose: To correlate the optical coherence tomography (OCT) based morphological patterns of diabetic macular edema (DME) and prognostic biomarkers with severity of anaemia in patients with diabetic kidney disease (DKD).Patients and methods: Single centre, observational cross sectional study of 42 eyes of 42 patients with DME and DKD. Eyes were divided into 2 groups: Group A (Haemoglobin level above 10 g% and group B with haemoglobin less than 10 g%). The OCT pattern and biomarkers were compared between the two groups.Results: Mean age of the patients was 56.9 ± 8.1 (range 42-79). Out of 42 participants, 22 patients had hemoglobin level more than 10g%(group A) while 20 patients had hemoglobin less than 10g%(Group B). The most common morphological pattern seen was combination of cystoid macular edema (CME) with diffuse retinal thickening (DRT) in both groups. Disruption of the external limiting membrane (ELM) and ellipsoid zone (EZ) was found to be associated with lower hemoglobin levels (p= 0.0155 and p= 0.0154 respectively). None of the other OCT biomarkers showed correlation with hemoglobin levels.Conclusion: CME with DRT is the most common morphological pattern of macular edema seen in DKD patients with anemia. ELM-EZ disruption can be considered as important biomarker of anaemia in patients with DKD.","PeriodicalId":93945,"journal":{"name":"Clinical ophthalmology (Auckland, N.Z.)","volume":"19 ","pages":"209-215"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762014/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical ophthalmology (Auckland, N.Z.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/OPTH.S447826","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: To correlate the optical coherence tomography (OCT) based morphological patterns of diabetic macular edema (DME) and prognostic biomarkers with severity of anaemia in patients with diabetic kidney disease (DKD).

Patients and methods: Single centre, observational cross sectional study of 42 eyes of 42 patients with DME and DKD. Eyes were divided into 2 groups: Group A (Haemoglobin level above 10 g% and group B with haemoglobin less than 10 g%). The OCT pattern and biomarkers were compared between the two groups.

Results: Mean age of the patients was 56.9 ± 8.1 (range 42-79). Out of 42 participants, 22 patients had hemoglobin level more than 10g%(group A) while 20 patients had hemoglobin less than 10g%(Group B). The most common morphological pattern seen was combination of cystoid macular edema (CME) with diffuse retinal thickening (DRT) in both groups. Disruption of the external limiting membrane (ELM) and ellipsoid zone (EZ) was found to be associated with lower hemoglobin levels (p= 0.0155 and p= 0.0154 respectively). None of the other OCT biomarkers showed correlation with hemoglobin levels.

Conclusion: CME with DRT is the most common morphological pattern of macular edema seen in DKD patients with anemia. ELM-EZ disruption can be considered as important biomarker of anaemia in patients with DKD.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

目的：将基于光学相干断层扫描（OCT）的糖尿病黄斑水肿（DME）形态模式和预后生物标志物与糖尿病肾病（DKD）患者的贫血严重程度相关联：单中心观察性横断面研究：42 位 DME 和 DKD 患者的 42 只眼睛。患者分为两组：A组（血红蛋白水平高于10 g%，B组血红蛋白水平低于10 g%）。比较了两组的 OCT 模式和生物标志物：患者的平均年龄为 56.9 ± 8.1（42-79 岁）。在 42 名参与者中，22 名患者的血红蛋白水平超过 10g%（A 组），20 名患者的血红蛋白水平低于 10g%（B 组）。两组中最常见的形态模式都是囊样黄斑水肿（CME）和弥漫性视网膜增厚（DRT）。研究发现，外缘膜（ELM）和椭圆带（EZ）的破坏与血红蛋白水平较低有关（分别为 p= 0.0155 和 p=0.0154）。结论：结论：伴有DRT的CME是贫血的DKD患者最常见的黄斑水肿形态模式。ELM-EZ破坏可被视为DKD患者贫血的重要生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Clinical ophthalmology (Auckland, N.Z.)

CiteScore

4.10

自引率

0.00%

发文量