Targeting GSK3 to attenuate spaceflight-induced SERCA dysfunction: Lessons from hindlimb-suspended mice

IF 4.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2025-01-27 DOI:10.1016/j.bbadis.2025.167694

Amélie A.T. Marais, Ryan W. Baranowski, Jessica L. Braun, Briana L. Hockey, Val A. Fajardo

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引用次数: 0

Abstract

•
In the absence of gravity, muscles become unloaded, reducing their size, strength, and endurance.
•
Calcium (Ca²⁺) dysregulation due to impairments in sarco(endo)plasmic reticulum Ca²⁺-ATPase (SERCA) function may be one reason for the decline in muscle performance.
•
Our previous work has shown that genetic reduction of glycogen synthase kinase 3 (GSK3) maintains soleus muscle mass and strength in mice after 7 days of hindlimb suspension.
•
Here, we tested whether these benefits could be, in part, due to an improvement in SERCA activity.
•
We show that muscle-specific GSK3 knockdown enhances soleus maximal SERCA activity, SERCA1 protein content, soleus relaxation and soleus muscle endurance.

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以 GSK3 为靶点减轻太空飞行诱发的 SERCA 功能障碍：后肢悬空小鼠的启示

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来源期刊

Biochimica et biophysica acta. Molecular basis of disease 生物-生化与分子生物学

CiteScore

12.30

自引率

0.00%

发文量

218

审稿时长

32 days

期刊介绍： BBA Molecular Basis of Disease addresses the biochemistry and molecular genetics of disease processes and models of human disease. This journal covers aspects of aging, cancer, metabolic-, neurological-, and immunological-based disease. Manuscripts focused on using animal models to elucidate biochemical and mechanistic insight in each of these conditions, are particularly encouraged. Manuscripts should emphasize the underlying mechanisms of disease pathways and provide novel contributions to the understanding and/or treatment of these disorders. Highly descriptive and method development submissions may be declined without full review. The submission of uninvited reviews to BBA - Molecular Basis of Disease is strongly discouraged, and any such uninvited review should be accompanied by a coverletter outlining the compelling reasons why the review should be considered.