Tailorable biosensors for real-time monitoring of stress distribution in soft biomaterials and living tissues

IF 14.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Nature Communications Pub Date : 2025-01-27 DOI:10.1038/s41467-025-56422-8
Fenghou Yuan, Huitang Qi, Binghui Song, Yuntian Cui, Junsheng Zhang, Huan Liu, Bo Liu, Hai Lei, Tian Liu
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Abstract

Visualizing mechanical stress distribution in soft and live biomaterials is essential for understanding biological processes and improving material design. However, it remains challenging due to their complexity, dynamic nature, and sensitivity requirements, necessitating innovative techniques. Since polysaccharides are common in various biomaterials, a biosensor integrating a Förster resonance energy transfer (FRET)-based tension sensor module and carbohydrate-binding modules (FTSM-CBM) has been designed for real-time monitoring of the stress distribution of these biomaterials. By simple dripping or soaking, FTSM-CBM enables fast, reproducible and semiquantitative detection of both 2D and 3D stress distributions in polysaccharide-based hydrogels. Additionally, it provides valuable information such as microstructure hints and fracture site warnings. FTSM-CBM can also monitor the locomotion of maggots, which is not feasible with most existing techniques. Furthermore, by changing the CBM, FTSM-CBM can be expanded for various polysaccharide-based biomaterials. This study provides a powerful tool that may promote related research in life and materials science.

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来源期刊
Nature Communications
Nature Communications Biological Science Disciplines-
CiteScore
24.90
自引率
2.40%
发文量
6928
审稿时长
3.7 months
期刊介绍: Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.
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