{"title":"Evasion of T cell responses by newly emerging SARS-CoV-2 variants","authors":"","doi":"10.1038/s41590-024-02053-y","DOIUrl":null,"url":null,"abstract":"We describe how newly emerging mutations in the SARS-CoV-2 variant BA.2.86 sub-variant JN.1 contribute to evasion of CD8+ T cell responses. Mutations occurring in T cell epitope hotspots in the viral spike protein and in a highly conserved site in the viral nucleocapsid suggest that T cell-mediated immune pressure is a key driving force for SARS-CoV-2 evolution and adaptation.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"36 1","pages":""},"PeriodicalIF":27.7000,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41590-024-02053-y","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
We describe how newly emerging mutations in the SARS-CoV-2 variant BA.2.86 sub-variant JN.1 contribute to evasion of CD8+ T cell responses. Mutations occurring in T cell epitope hotspots in the viral spike protein and in a highly conserved site in the viral nucleocapsid suggest that T cell-mediated immune pressure is a key driving force for SARS-CoV-2 evolution and adaptation.
期刊介绍：
Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.
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