Adoption of Electrochemistry within the Pharmaceutical Industry: Insights from an Industry-Wide Survey

IF 3.5 3区 化学 Q2 CHEMISTRY, APPLIED Organic Process Research & Development Pub Date : 2025-01-27 DOI:10.1021/acs.oprd.4c00353
Antonio C. Ferretti, Benjamin Cohen, Lin Deng, Moiz Diwan, Michael O. Frederick, Dan Lehnherr
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Abstract

This article presents the results of a comprehensive survey on the adoption of electrochemistry among 17 major pharmaceutical companies. The study examined key areas, including motivation, vision, personnel, utilization, explored reactions, scale-up experience, and equipment, with a focus on identifying gaps that hinder the realization of electrochemistry’s full potential. The survey findings suggest that although the adoption of electrochemistry is still in its early stages, it is viewed as a promising area that could lead to novel, better, and differentiated chemical transformations and disruptive routes. None of the surveyed companies reported having commercialized electrochemical processes; however, many anticipate reaching late-stage development or commercialization within a few years. The survey provides valuable insights for both industrial and academic laboratories seeking to pursue research in this field. Addressing gaps in knowledge and technology is essential to realizing the potential benefits of electrochemistry, ultimately contributing to the development of more efficient and sustainable manufacturing processes in the pharmaceutical industry.

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在制药工业中采用电化学:来自全行业调查的见解
本文介绍了对17家主要制药公司采用电化学的综合调查结果。该研究考察了关键领域,包括动力、愿景、人员、利用、探索反应、扩大规模的经验和设备,重点是确定阻碍实现电化学全部潜力的差距。调查结果表明,尽管电化学的应用仍处于早期阶段,但它被视为一个有前途的领域,可能会导致新的、更好的、差异化的化学转化和破坏性的途径。被调查的公司中没有一家报告已将电化学工艺商业化;然而,许多人预计在几年内进入后期开发或商业化阶段。该调查为寻求在该领域进行研究的工业和学术实验室提供了有价值的见解。解决知识和技术上的差距对于实现电化学的潜在利益至关重要,最终有助于制药行业开发更高效和可持续的制造工艺。
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来源期刊
CiteScore
6.90
自引率
14.70%
发文量
251
审稿时长
2 months
期刊介绍: The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools,process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.
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