CSF cytokine, chemokine and injury biomarker profile of glial fibrillary acidic protein (GFAP) autoimmunity

IF 3.9 2区医学 Q1 CLINICAL NEUROLOGY Annals of Clinical and Translational Neurology Pub Date : 2025-01-27 DOI:10.1002/acn3.52305

Yahel Segal, Georgios Mangioris, Vanda Lennon, Binxia Yang, Divyanshu Dubey, Eoin P. Flanagan, Andrew McKeon, John R. Mills, Michel Toledano, Ivana Vodopivec, Sean J. Pittock, Anastasia Zekeridou

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Abstract

Defining the CSF cytokine/chemokine and injury biomarker signature of glial fibrillary acidic protein (GFAP) autoimmunity can inform immunopathogenesis. CSF GFAP-IgG-positive samples (N = 98) were tested for 17 cytokines/chemokines, neurofilament light chain (NfL), and GFAP (ELLA, Bio-Techne). Controls included non-inflammatory (N = 42), AQP4-IgG-positive (N = 83), CNS infections (N = 13), and neurosarcoidosis (N = 32). IL5, IL6, IL10, IL8/CXCL8, CXCL9, CXCL10, CXCL13, BAFF, GM-CSF, IFN-gamma, and TNF-alpha concentrations were higher compared to non-inflammatory controls (P < 0.01). GFAP concentrations were similar to those of AQP4-IgG-positive patients; NfL was higher (P < 0.001) and correlated with MRI changes and outcomes. CSF cytokine/chemokine findings in GFAP autoimmunity correlate with histopathology; GFAP and NfL hold promise as disease biomarkers.

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胶质纤维酸性蛋白（GFAP）自身免疫的CSF细胞因子、趋化因子和损伤生物标志物谱。

确定胶质纤维酸性蛋白（GFAP）自身免疫的脑脊液细胞因子/凝血因子和损伤生物标志物特征可为免疫发病机制提供信息。对 CSF GFAPgG 阳性样本（N = 98）进行了 17 种细胞因子/凝血因子、神经丝蛋白轻链（NfL）和 GFAP（ELLA，Bio-Techne）检测。对照组包括非炎症性（42 例）、AQP4-IgG 阳性（83 例）、中枢神经系统感染（13 例）和神经肉芽肿病（32 例）。与非炎症对照组相比，IL5、IL6、IL10、IL8/CXCL8、CXCL9、CXCL10、CXCL13、BAFF、GM-CSF、IFN-gamma 和 TNF-α 的浓度更高（P＜0.05）。

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来源期刊

Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)

CiteScore

9.10

自引率

1.90%

发文量

218

审稿时长

8 weeks

期刊介绍： Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.