Association of Suicidal Status, Inflammation Markers, and Resting-State Functional Activity and Connectivity in Patients With Major Depressive Disorder.

IF 4.5 2区医学 Q1 PSYCHIATRY Journal of Clinical Psychiatry Pub Date : 2024-06-26 DOI:10.4088/JCP.23m15148

Emilie Olié, Guillaume Clain, Manon Malestroit, Dimitri Fiedos, Fabrice Cognasse, Jeremy Deverdun, Emmanuelle Le Bars, Philippe Courtet

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Abstract.

Background: This study aimed to identify (1) neural markers of suicide attempt using resting-state functional magnetic resonance imaging (rs-fMRI) and (2) associations between rs-fMRI metrics and resting-state functional connectivity (rs-FC), suicidal phenotype, and peripheral blood inflammation markers.

Methods: Inflammation markers (C-reactive protein [CRP], interleukin [IL]-1β, IL-2, and IL-6, and tumor necrosis factor-α TNF-α) and rs-fMRI metrics were measured in 20 healthy controls (HCs) and 42 patients with unipolar depression according to the DSM-5 criteria (n = 21 suicide attempters [SAs] in the last 8 days and n = 21 affective controls [ACs] without lifetime suicidal history) between February 1 and November 30, 2017. Amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), voxel-mirrored homotopic connectivity, and rs-FC were estimated in prefrontal cortex, anterior cingulate cortex, and insula.

Results: Participants were mainly women (age: 40-48 years). Only CRP concentration was higher in SAs than in ACs and HCs (3.55 [0.5; 13.3] vs 0.6 [0.3; 4.4] vs 0.8 [0.3; 13.9] mg/L, respectively, P < 10^-3). ALFF values in the pars opercularis of the inferior frontal gyrus (IFG) were lower in SAs than in ACs and HCs (all P < 10^-2), even after controlling for suicidal ideation intensity and CRP level. Suicidal ideation was negatively correlated with all rs-fMRI metrics (except ReHo of left side) of this region in patients. The rs-FC values of bilateral anterior cingulate cortex, left orbital IFG, and middle frontal orbital gyrus were higher in SAs than in ACs and HCs (all P < .05).

Conclusions: Resting-state activity and connectivity in regions involved in language, cognitive control, and decision making may be associated with suicidal behaviors, but not with inflammation markers.

Trial Registration: ClinicalTrials.gov identifier: NCT03052855.

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重度抑郁症患者的自杀状态、炎症标志物、静息状态功能活动和连接性之间的关系

摘要.背景：本研究旨在利用静息态功能磁共振成像（rs-fMRI）确定（1）自杀未遂的神经标志物；（2）rs-fMRI指标与静息态功能连接（rs-FC）、自杀表型和外周血炎症标志物之间的关联：在2017年2月1日至11月30日期间，对20名健康对照组（HCs）和42名符合DSM-5标准的单相抑郁症患者（n = 21名过去8天内有自杀企图者[SAs]和n = 21名一生无自杀史的情感对照组[ACs]）的炎症标志物（C-反应蛋白[CRP]、白细胞介素[IL]-1β、IL-2和IL-6以及肿瘤坏死因子-α TNF-α）和rs-fMRI指标进行了测量。对前额叶皮层、前扣带回皮层和岛叶的低频波动幅度（ALFF）、区域同质性（ReHo）、体映同位连通性和rs-FC进行了估计：参与者主要为女性（年龄：40-48 岁）。只有SA的CRP浓度高于AC和HC（分别为3.55 [0.5; 13.3] vs 0.6 [0.3; 4.4] vs 0.8 [0.3; 13.9] mg/L，P < 10-3）。即使在控制了自杀意念强度和 CRP 水平后，SAs 额叶下回（IFG）厣旁的 ALFF 值仍低于 ACs 和 HCs（均 P < 10-2）。自杀意念与患者该区域的所有 rs-fMRI 指标（左侧 ReHo 除外）均呈负相关。双侧前扣带回皮层、左侧眼眶IFG和中额叶眼眶回的rs-FC值在SAs中高于ACs和HCs（所有P < .05）：语言、认知控制和决策区域的静息态活动和连通性可能与自杀行为有关，但与炎症指标无关：试验注册：ClinicalTrials.gov identifier：NCT03052855。

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来源期刊

Journal of Clinical Psychiatry 医学-精神病学

CiteScore

7.40

自引率

1.90%

发文量

审稿时长

3-8 weeks

期刊介绍： For over 75 years, The Journal of Clinical Psychiatry has been a leading source of peer-reviewed articles offering the latest information on mental health topics to psychiatrists and other medical professionals.The Journal of Clinical Psychiatry is the leading psychiatric resource for clinical information and covers disorders including depression, bipolar disorder, schizophrenia, anxiety, addiction, posttraumatic stress disorder, and attention-deficit/hyperactivity disorder while exploring the newest advances in diagnosis and treatment.