{"title":"mSphere of Influence: The challenge of screening for essential protein kinases in <i>Trypanosoma cruzi</i>.","authors":"Miguel A Chiurillo","doi":"10.1128/msphere.00598-24","DOIUrl":null,"url":null,"abstract":"<p><p>Miguel Chiurillo works in the field of protein kinases, studying their role in cell signaling and cell cycle progression in <i>Trypanosoma cruzi</i>. In this mSphere of Influence article, he reflects on how the research articles \"Systematic functional analysis of <i>Leishmania</i> protein kinases identifies regulators of differentiation or survival\" by Baker et al. and \"Screening the <i>Toxoplasma</i> kinome with high throughput tagging identifies a regulator of invasion and egress\" by Smith et al. made an impact on his understanding of the complexity of the <i>Trypanosoma cruzi</i> kinome and the challenges to unravel it.</p>","PeriodicalId":19052,"journal":{"name":"mSphere","volume":" ","pages":"e0059824"},"PeriodicalIF":3.7000,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"mSphere","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1128/msphere.00598-24","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Miguel Chiurillo works in the field of protein kinases, studying their role in cell signaling and cell cycle progression in Trypanosoma cruzi. In this mSphere of Influence article, he reflects on how the research articles "Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival" by Baker et al. and "Screening the Toxoplasma kinome with high throughput tagging identifies a regulator of invasion and egress" by Smith et al. made an impact on his understanding of the complexity of the Trypanosoma cruzi kinome and the challenges to unravel it.
期刊介绍：
mSphere™ is a multi-disciplinary open-access journal that will focus on rapid publication of fundamental contributions to our understanding of microbiology. Its scope will reflect the immense range of fields within the microbial sciences, creating new opportunities for researchers to share findings that are transforming our understanding of human health and disease, ecosystems, neuroscience, agriculture, energy production, climate change, evolution, biogeochemical cycling, and food and drug production. Submissions will be encouraged of all high-quality work that makes fundamental contributions to our understanding of microbiology. mSphere™ will provide streamlined decisions, while carrying on ASM''s tradition for rigorous peer review.
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