Hepatic eosinophilic pseudotumor due to Fasciola hepatica infection mimicking intrahepatic cholangiocarcinoma: A case report.

IF 2.5 Q2 GASTROENTEROLOGY & HEPATOLOGY World Journal of Hepatology Pub Date : 2025-01-27 DOI:10.4254/wjh.v17.i1.101664

Kim-Long Le, Minh-Quang Tran, Tri-Nhan Pham, Nhu Ngoc-Quynh Duong, Thien Thuan Dinh, Nguyen-Khoi Le

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Abstract

Background: Hepatic eosinophilic pseudotumor (HEPT) is a rare condition that mimics malignant hepatic tumors, posing significant diagnostic challenges. This case report highlights the importance of considering parasitic infections like Fasciola hepatica (F. hepatica) in the differential diagnosis of hepatic masses, especially in endemic regions, to prevent unnecessary interventions.

Case summary: A 40-year-old female presented with a 1-month history of epigastric pain and significant weight loss. Imaging revealed a hepatic mass, initially misdiagnosed as intrahepatic cholangiocarcinoma. Laboratory results showed marked eosinophilia, and histopathological examination confirmed significant eosinophilic infiltration without malignancy. Serological testing identified F. hepatica infection. The patient was treated with a single dose of triclabendazole, leading to complete symptom resolution and normalization of hepatic imaging findings within days.

Conclusion: HEPT due to F. hepatica can closely mimic malignancy; timely antiparasitic treatment is crucial for resolution.

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模仿肝内胆管癌的肝嗜酸性假瘤：病例报告。

背景：肝嗜酸性假瘤（HEPT）是一种罕见的疾病，它模仿恶性肝肿瘤，给诊断带来了巨大挑战。本病例报告强调了在肝脏肿块的鉴别诊断中考虑肝脏法氏囊（F. hepatica）等寄生虫感染的重要性，尤其是在地方病流行地区，以避免不必要的干预。影像学检查发现肝脏肿块，最初误诊为肝内胆管癌。实验室检查结果显示有明显的嗜酸性粒细胞增多，组织病理学检查证实有明显的嗜酸性粒细胞浸润，但无恶性病变。血清学检测确定感染了肝蝇。患者接受了单剂量三苯咪唑治疗，症状完全缓解，肝脏影像学检查结果也在数天内恢复正常：结论：肝包虫导致的肝纤维化可与恶性肿瘤密切相关；及时的抗寄生虫治疗是缓解症状的关键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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