Melanoma in a Colombian population: a survival study.

IF 1 Q4 ONCOLOGY Melanoma Management Pub Date : 2024-12-01 Epub Date: 2024-08-05 DOI:10.1080/20450885.2024.2382079
Mauricio Arias Flórez, Germán Alberto Moreno Gómez, Mateo Aguirre Flórez, Isaac López Bueno, Juanita Moreno Gómez, Mateo Moreno Gómez, Juan José Restrepo Gutiérrez
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Abstract

Background: Melanoma, the deadliest skin cancer, presents significant challenges globally. This study examines survival factors among patients treated at a high-complexity oncology center in Colombia's coffee-growing region. Methods: Records from 2010 to 2021 were analyzed, capturing socio-demographics, clinical variables and survival outcomes via Kaplan-Meier and Cox regression. Results: Among 766 patients, factors influencing survival included sex, TNM stage, diagnostic stage, ulceration, metastasis, Breslow thickness ≥1 mm and positive nodes. Age, ulceration, distant stage at diagnosis and Breslow thickness ≥1 mm were associated with mortality. Conclusion: Colombian melanoma patients exhibit lower survival rates compared with global trends. Key survival determinants align with international literature. Enhanced photoprotection and early detection initiatives are imperative.

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背景:黑色素瘤是最致命的皮肤癌,给全球带来了巨大挑战。本研究探讨了在哥伦比亚咖啡种植区一家高难度肿瘤中心接受治疗的患者的生存因素。研究方法分析 2010 年至 2021 年的记录,通过 Kaplan-Meier 和 Cox 回归分析社会人口统计学、临床变量和生存结果。结果在766名患者中,影响生存的因素包括性别、TNM分期、诊断分期、溃疡、转移、布瑞斯罗厚度≥1毫米和阳性结节。年龄、溃疡、诊断时的远处分期和布氏厚度≥1毫米与死亡率有关。结论与全球趋势相比,哥伦比亚黑色素瘤患者的存活率较低。决定存活率的关键因素与国际文献一致。加强光防护和早期检测措施势在必行。
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来源期刊
CiteScore
5.10
自引率
0.00%
发文量
4
审稿时长
13 weeks
期刊介绍: Skin cancer is on the rise. According to the World Health Organization, 132,000 melanoma skin cancers occur globally each year. While early-stage melanoma is usually relatively easy to treat, once disease spreads prognosis worsens considerably. Therefore, research into combating advanced-stage melanoma is a high priority. New and emerging therapies, such as monoclonal antibodies, B-RAF and KIT inhibitors, antiangiogenic agents and novel chemotherapy approaches hold promise for prolonging survival, but the search for a cure is ongoing. Melanoma Management publishes high-quality peer-reviewed articles on all aspects of melanoma, from prevention to diagnosis and from treatment of early-stage disease to late-stage melanoma and metastasis. The journal presents the latest research findings in melanoma research and treatment, together with authoritative reviews, cutting-edge editorials and perspectives that highlight hot topics and controversy in the field. Independent drug evaluations assess newly approved medications and their role in clinical practice. Key topics covered include: Risk factors, prevention and sun safety education Diagnosis, staging and grading Surgical excision of melanoma lesions Sentinel lymph node biopsy Biological therapies, including immunotherapy and vaccination Novel chemotherapy options Treatment of metastasis Prevention of recurrence Patient care and quality of life.
期刊最新文献
BRAF-mutant melanoma management: a single center retrospective analysis of patients treated with sequential therapy. Immune checkpoint inhibitors in pediatric patients with melanoma: a systematic literature review. Melanoma in a Colombian population: a survival study. A rare and challenging case of amelanotic subungual melanoma from Syria. Patterns in progression from early-stage melanoma to late-stage melanoma: implications for survivorship follow-up.
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