Potential mechanisms and therapeutic prospects of the association between Helicobacter pylori infection and metabolic dysfunction-associated steatohepatitis.

Abstract

Helicobacter pylori (H. pylori) infection is a known inducer of various gastrointestinal diseases, including gastritis, gastric ulcers, and gastric cancer. However, in recent years, research on the potential association between H. pylori infection and metabolic dysfunction-associated steatohepatitis (MASH) has been scarce. This large-scale multicenter study, covering more than 360 hospitals across 26 medical systems in the United States, systematically evaluated the association between H. pylori infection and MASH. This paper reviews the innovative aspects of this study, discusses its significance in the current research field of H. pylori and liver diseases, analyzes potential molecular mechanisms, and suggests future research directions and therapeutic prospects.