Fatima Zahra Mekrane, Radouane Ouladsine, Abdelwahed Barkaoui, Raymond Ghandour
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引用次数: 0
Abstract
Repetitive mechanical stresses on the knee joint during daily activities accumulate fatigue damage in the articular cartilage (AC), leading to wear and knee osteoarthritis (KOA). Effective treatments remain limited, underscoring the need for predictive approaches to identify KOA early. This study proposes a mathematical model to estimate AC degradation under cyclic loading from walking. By integrating Miner's rule, Monte Carlo simulations, and Weibull distributions, the model predicts remaining cycles before AC loses 60% of its volume, a critical KOA threshold. Verified against a well-established model, it offers potential for personalized strategies to prevent or delay KOA progression.
期刊介绍：
The primary aims of Computer Methods in Biomechanics and Biomedical Engineering are to provide a means of communicating the advances being made in the areas of biomechanics and biomedical engineering and to stimulate interest in the continually emerging computer based technologies which are being applied in these multidisciplinary subjects. Computer Methods in Biomechanics and Biomedical Engineering will also provide a focus for the importance of integrating the disciplines of engineering with medical technology and clinical expertise. Such integration will have a major impact on health care in the future.
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