Progress in spinal cord organoid research: advancing understanding of neural development, disease modelling, and regenerative medicine.

Biomaterials Translational Pub Date : 2024-11-15 eCollection Date: 2024-01-01 DOI:10.12336/biomatertransl.2024.04.003

Ruiqi Huang, Yanjing Zhu, Haokun Chen, Liqun Yu, Zhibo Liu, Yuchen Liu, Zhaojie Wang, Xiaolie He, Li Yang, Xu Xu, Yuxin Bai, Bairu Chen, Rongrong Zhu

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Abstract

Stem cell-derived spinal cord organoids (SCOs) have revolutionised the study of spinal cord development and disease mechanisms, offering a three-dimensional model that recapitulates the complexity of native tissue. This review synthesises recent advancements in SCO technology, highlighting their role in modelling spinal cord morphogenesis and their application in neurodegenerative disease research. We discuss the methodological breakthroughs in inducing regional specification and cellular diversity within SCOs, which have enhanced their predictive ability for drug screening and their relevance in mimicking pathological conditions such as neurodegenerative diseases and neuromuscular disorders. Despite these strides, challenges in achieving vascularisation and mature neuronal integration persist. The future of SCOs lies in addressing these limitations, potentially leading to transformative impactions in regenerative medicine and therapeutic development.

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脊髓类器官研究进展：促进对神经发育、疾病建模和再生医学的理解。

干细胞衍生的脊髓类器官（SCOs）已经彻底改变了脊髓发育和疾病机制的研究，提供了一个概括天然组织复杂性的三维模型。本文综述了SCO技术的最新进展，强调了它们在模拟脊髓形态发生中的作用及其在神经退行性疾病研究中的应用。我们讨论了在SCOs内诱导区域规格和细胞多样性的方法上的突破，这些突破增强了SCOs对药物筛选的预测能力，以及它们在模拟神经退行性疾病和神经肌肉疾病等病理状况方面的相关性。尽管取得了这些进步，但在实现血管化和成熟神经元整合方面的挑战仍然存在。SCOs的未来在于解决这些限制，可能导致再生医学和治疗发展的变革性影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomaterials Translational

CiteScore

6.70

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0.00%

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