Loss of B cell protection in uraemic kidney disease

IF 39.8 1区医学 Q1 UROLOGY & NEPHROLOGY Nature Reviews Nephrology Pub Date : 2025-01-29 DOI:10.1038/s41581-025-00936-3

Monica Wang

引用次数: 0

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尿毒性肾病中B细胞保护功能的丧失

导致肾脏疾病患者免疫力受损的机制尚不清楚。Partha Biswas及其同事的一项研究现在将一种尿毒症毒素与小鼠生发中心（GC） B细胞反应缺陷联系起来。基因表达分析和细胞染色表明，与对照组相比，KD小鼠GC - B细胞增殖减少，凋亡增加。在体外，将细胞质母细胞暴露于晚期KD患者中观察到的浓度的尿毒症毒素中，发现可以结合GPR109A（由Niacr1编码）的马尿酸增加了细胞质母细胞的凋亡。研究人员发现，在KD动物中观察到的GC反应缺陷依赖于GPR109A的存在，因为Niacr1 - / - aa诱导的KD动物仍然具有正常的GC反应。此外，当B细胞缺陷小鼠接受Niacr1 - / - B细胞时，AA诱导KD不影响免疫后检测到的np特异性B细胞的数量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Nephrology 医学-泌尿学与肾脏学

CiteScore

39.00

自引率

1.20%

发文量

127

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves. It strives to publish authoritative, accessible articles. Articles are enhanced with clearly understandable figures, tables, and other display items. Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements. The content is relevant to nephrologists and basic science researchers. The broad scope of the journal ensures that the work reaches the widest possible audience.

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