{"title":"Unlocking drug modes of action with multi-dimensional high-throughput metabolic profiling","authors":"","doi":"10.1038/s41587-024-02525-4","DOIUrl":null,"url":null,"abstract":"Large-scale profiling of drug-induced metabolic changes have potential for improving drug development but remain challenging. We created a computational and experimental large-scale metabolic profiling framework that enabled us to map metabolic effects for 1,520 diverse drugs. This platform revealed new modes of action and potential therapeutic uses for already market-approved drugs.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"47 1","pages":""},"PeriodicalIF":33.1000,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1038/s41587-024-02525-4","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Large-scale profiling of drug-induced metabolic changes have potential for improving drug development but remain challenging. We created a computational and experimental large-scale metabolic profiling framework that enabled us to map metabolic effects for 1,520 diverse drugs. This platform revealed new modes of action and potential therapeutic uses for already market-approved drugs.
期刊介绍:
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