Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's disease

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2025-01-29 DOI:10.1002/alz.14424

Arsenio Páez, Sam O. Gillman, Shahla Bakian Dogaheh, Anna Carnes, Faride Dakterzada, Ferran Barbé, Thien Thanh Dang-Vu, Gerard Piñol Ripoll

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Abstract

INTRODUCTION

Changes in sleep physiology can predate cognitive symptoms by decades in persons with Alzheimer's disease (AD), but it remains unclear which sleep characteristics predict cognitive and neurodegenerative changes after AD onset.

METHODS

Using data from a prospective cohort of mild to moderate AD (n = 60), we analyzed non-rapid eye movement sleep spindles and slow oscillations (SOs) at baseline and their associations with baseline amyloid beta (Aβ) and tau and with cognition from baseline to 3-year follow-up.

RESULTS

Higher spindle and SO activity predicted significant changes in Aβ and tau at baseline, lower Alzheimer's Disease Assessment Scale Cognitive Subscale (better cognitive performance) score, and higher Mini-Mental State Examination score from baseline to 36 months. Spindles and SOs mediated the effect of phosphorylated tau 181 (pTau181)/Aβ42 on cognition, while pTau181/aβ42 moderated the effect of spindles and SOs on cognition.

DISCUSSION

Our findings demonstrate that spindle and SO activity during sleep constitute predictive and non-invasive biomarkers of neurodegeneration and cognition in AD patients.

Highlights

Sleep spindles predict long-term cognitive performance in AD.
Sleep spindle and SOs can be predictive, non-invasive biomarkers for AD.
Sleep may be one of the most important modifiable risk factors for AD progression.
Sleep microarchitecture is a novel therapeutic target for preserving brain heath.
Sleep physiology can provide novel therapeutic targets to slow AD progression.

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睡眠纺锤波和慢振荡预测轻度至中度阿尔茨海默病的认知和神经变性的生物标志物

在阿尔茨海默病（AD）患者中，睡眠生理学的变化可以在认知症状出现之前几十年就发生，但目前尚不清楚哪些睡眠特征可以预测AD发病后的认知和神经退行性变化。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.