Iron-associated lipid peroxidation in Alzheimer's disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice
Max A. Thorwald, Jose A. Godoy-Lugo, Gilberto Garcia, Justine Silva, Minhoo Kim, Amy Christensen, Wendy J. Mack, Elizabeth Head, Peggy A. O'Day, Bérénice A. Benayoun, Todd E. Morgan, Christian J. Pike, Ryo Higuchi-Sanabria, Henry Jay Forman, Caleb E. Finch
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引用次数: 0
Abstract
Iron-mediated cell death (ferroptosis) is a proposed mechanism of Alzheimer's disease (AD) pathology. While iron is essential for basic biological functions, its reactivity generates oxidants which contribute to cell damage and death.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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