Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation

IF 20.4 1区医学 Q1 CELL & TISSUE ENGINEERING Cell stem cell Pub Date : 2025-01-28 DOI:10.1016/j.stem.2025.01.007

Yaobin Jing, Xiaoyu Jiang, Qianzhao Ji, Zeming Wu, Wei Wang, Zunpeng Liu, Pedro Guillen-Garcia, Concepcion Rodriguez Esteban, Pradeep Reddy, Steve Horvath, Jingyi Li, Lingling Geng, Qinchao Hu, Si Wang, Juan Carlos Izpisua Belmonte, Jie Ren, Weiqi Zhang, Jing Qu, Guang-Hui Liu

引用次数: 0

Abstract

(Cell Stem Cell 30, 1452–1471.e1–e10; November 2, 2023)

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

衰老细胞的全基因组CRISPR激活筛选揭示了SOX5作为年轻化的驱动因素和治疗靶点

(细胞干细胞30,1452-1471.e1-e10；2023年11月2日)

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.

期刊最新文献

Turning drivers into regulators: In vivo CAR reprogramming of Tfh cells Less is more: Reducing zinc to boost stem cell-derived islet function and survival A sound link: Hearing, neurogenesis, and cognition Endogenous aldehydes: A driver of clonal hematopoiesis from within? Rebuilding the bridge: Functional AVN cells for cardiac repair