Yang'en You, Zhongjian Du, Chenlei Ji, Xu Wang, Zhenyu Wang, Zhenguo Guo
{"title":"FeCl3 promoted cycloisomerization of 1,6-dienes","authors":"Yang'en You, Zhongjian Du, Chenlei Ji, Xu Wang, Zhenyu Wang, Zhenguo Guo","doi":"10.1039/d4qo02201g","DOIUrl":null,"url":null,"abstract":"A highly selective cycloisomerization of 1,6-dienes by FeCl3 catalysis has been developed. Both symmetric and unsymmetric dienes could undergo this cycloisomerization through a carbocation pathway activated by Lewis acid FeCl3. This protocol offers a green approach to access α-alkenyl-tetrahydropyridine compounds with high yields and good selectivity.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"120 1","pages":""},"PeriodicalIF":4.6000,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Chemistry Frontiers","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4qo02201g","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
A highly selective cycloisomerization of 1,6-dienes by FeCl3 catalysis has been developed. Both symmetric and unsymmetric dienes could undergo this cycloisomerization through a carbocation pathway activated by Lewis acid FeCl3. This protocol offers a green approach to access α-alkenyl-tetrahydropyridine compounds with high yields and good selectivity.
期刊介绍:
Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.