Zhongjian Du , Chenlei Ji , Xu Wang , Zhenyu Wang , Zhenguo Guo , Yang'en You
{"title":"FeCl3 promoted cycloisomerization of 1,6-dienes†","authors":"Zhongjian Du , Chenlei Ji , Xu Wang , Zhenyu Wang , Zhenguo Guo , Yang'en You","doi":"10.1039/d4qo02201g","DOIUrl":null,"url":null,"abstract":"<div><div>A highly selective cycloisomerization of 1,6-dienes by FeCl<sub>3</sub> catalysis has been developed. Both symmetric and unsymmetric dienes could undergo this cycloisomerization through a carbocation pathway activated by Lewis acid FeCl<sub>3</sub>. This protocol offers a green approach to access α-alkenyl-tetrahydropyridine compounds with high yields and good selectivity.</div></div>","PeriodicalId":94379,"journal":{"name":"Organic chemistry frontiers : an international journal of organic chemistry","volume":"12 7","pages":"Pages 2205-2211"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic chemistry frontiers : an international journal of organic chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S2052412925000774","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/29 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A highly selective cycloisomerization of 1,6-dienes by FeCl3 catalysis has been developed. Both symmetric and unsymmetric dienes could undergo this cycloisomerization through a carbocation pathway activated by Lewis acid FeCl3. This protocol offers a green approach to access α-alkenyl-tetrahydropyridine compounds with high yields and good selectivity.
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