Dekun Kong, Qian He, Dong-Mei Lin, Huaran Zhang, Lin Chen, Yanhua Fan, Man-Cheng Tang, Yi Zou
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引用次数: 0
Abstract
Some key secondary metabolism genes are important for driving the infection process of entomopathogenic fungi; however, their chemical substance basis has not been well investigated. Here, mixtures of polyol lipids are discovered, which are synthesized through iterative chain transfer–esterification–hydrolysis cycles catalyzed by serine hydrolase during the release of online highly reducing polyketide intermediates. Importantly, an in vivo gene knockout experiment revealed that the synthesis of polyol lipids is necessary for rodlet layer formation on the cell wall of Beauveria bassiana. Our work uncovers an unexpected way for the synthesis of polyol lipids and illuminates a new perspective on their part in significant physiological processes in entomopathogenic fungi.
期刊介绍:
The flagship journal of the American Chemical Society, known as the Journal of the American Chemical Society (JACS), has been a prestigious publication since its establishment in 1879. It holds a preeminent position in the field of chemistry and related interdisciplinary sciences. JACS is committed to disseminating cutting-edge research papers, covering a wide range of topics, and encompasses approximately 19,000 pages of Articles, Communications, and Perspectives annually. With a weekly publication frequency, JACS plays a vital role in advancing the field of chemistry by providing essential research.