What We Know About TMEM175 in Parkinson's Disease

IF 5 1区医学 Q1 NEUROSCIENCES CNS Neuroscience & Therapeutics Pub Date : 2025-01-20 DOI:10.1111/cns.70195

Jing Wang, Xuechun Sun, Lufeng Cheng, Meijie Qu, Chanyuan Zhang, Xueting Li, Lingyan Zhou

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Abstract

Background

Lysosome is a highly heterogeneous membranous organelle in eukaryotic cells, which regulates many physiological processes in the cell. Studies have found that lysosomal dysfunction disrupts cellular homeostasis and is associated with Parkinson's disease (PD). Transmembrane protein 175 (TMEM175) is a lysosomal cation channel whose activity is essential for lysosomal homeostasis. At present, it has been confirmed that TMEM175 is related to the pathogenesis of PD, but the relationship between the two remains unclear.

Aims

A thorough comprehension of the structure and function of TMEM175 would greatly contribute to elucidating the achievement of this objective. In this paper, the structure, composition, and function of TMEM175 and its relationship with PD will be reviewed.

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我们对帕金森病中TMEM175的了解

背景：溶酶体是真核细胞中一种高度异质性的膜细胞器，它调节着细胞内的许多生理过程。研究发现，溶酶体功能障碍破坏细胞稳态，与帕金森病（PD）有关。跨膜蛋白175 （TMEM175）是溶酶体阳离子通道，其活性对溶酶体稳态至关重要。目前已经证实TMEM175与PD的发病机制有关，但两者之间的关系尚不清楚。目的：深入了解TMEM175的结构和功能将有助于阐明这一目标的实现。本文综述了TMEM175的结构、组成、功能及其与PD的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.