Yiyi Chen, Qisheng Chen, Shuangquan Zhang, Kun Feng, Xianqiang Kong, Xiaohui Chen, Wenjuan Li, Zhong-Yan Cao
{"title":"I<sub>2</sub>-Catalyzed benzylation of NH-sulfoximines with diarylmethanes and alkylarenes.","authors":"Yiyi Chen, Qisheng Chen, Shuangquan Zhang, Kun Feng, Xianqiang Kong, Xiaohui Chen, Wenjuan Li, Zhong-Yan Cao","doi":"10.1039/d4ob01709a","DOIUrl":null,"url":null,"abstract":"<p><p>A practical transition metal-free approach for the selective benzylation of NH-sulfoximines has been disclosed by using simple elemental iodine as the catalyst and <i>tert</i>-butyl hydroperoxide (TBHP) as the terminal oxidant. Comparing with known methods for the construction of <i>N</i>-benzylated sulfoximines, our protocol shows broad substrate scope with respect to both diarylmethanes and alkylarenes, and can be conducted in air with good functional group tolerance.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic & Biomolecular Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4ob01709a","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
A practical transition metal-free approach for the selective benzylation of NH-sulfoximines has been disclosed by using simple elemental iodine as the catalyst and tert-butyl hydroperoxide (TBHP) as the terminal oxidant. Comparing with known methods for the construction of N-benzylated sulfoximines, our protocol shows broad substrate scope with respect to both diarylmethanes and alkylarenes, and can be conducted in air with good functional group tolerance.
期刊介绍：
Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
