Global, Regional, and National Burden of Male Breast Cancer, 1990–2021: A Systematic Analysis for the Global Burden of Disease Study 2021

IF 3.1 2区医学 Q2 ONCOLOGY Cancer Medicine Pub Date : 2025-01-29 DOI:10.1002/cam4.70632

Long Wang, Ping Wen, Qing Shao, Dongping Jiang, Yulan Zhao, Xiaohua Zeng

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Abstract

Background

Male breast cancer (MBC) is rare and often treated using evidence from female breast cancer (BC) trials due to limited male participation. Previous estimates lacked global coverage and completeness. We aimed to quantify the global MBC burden from 1990 to 2021 and evaluate its current status and trends.

Methods

Based on the global burden of disease (GBD) database, we gathered and analyzed data on the incidence, death, and disability-adjusted life years (DALYs) of MBC while utilizing age-standardized rates (ASRs) as indicators for these measurements. Our study calculated the estimated annual percentage change (EAPC), aiming at measuring the average change in ASRs. Additionally, we evaluated the attributable risk factors (RFs) and trends of MBC across different regions and age groups worldwide.

Results

In 2021, the global MBC age-standardized incidence rates (ASIR), age-standardized death rates (ASDR), and age-standardized DALY rates (ASDALY) per 100,000 persons were 0.941 (95% UI, 0.605–1.155), 0.335 (95% UI, 0.232–0.409), and 9.157 (95% UI, 6.116–11.423), respectively. In comparison to 1990, these rates have increased by 2.212 (95% UI, 2.047–2.378), 0.664 (95% UI, 0.562–0.767), and 0.853 (95% UI, 0.750–0.956) respectively. In Uganda 2021, the ASIR and ASDR of MBC were the highest at 4.541 (95% UI, 3.028–6.808) and 3.510 (95% UI, 2.301–5.195) per 100,000 persons, respectively. Moreover, the burden of MBC exhibited an increase with age. Globally, dietary risk was the most important attributable RF for MBC deaths, with a death percentage of 11.690% (95% UI, −0.003%–24.838%), followed by alcohol use and tobacco.

Conclusion

From 1990 to 2021, the ASIR, ASDR, and ASDALY of MBC have shown significant disparities and an increasing trend. Committing to healthy lifestyle choices, such as decreasing tobacco and alcohol consumption and making positive changes to dietary habits, can assist in reducing MBC risk. The development and execution of robust and effective public health policies are crucial for alleviating the global disease burden.

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1990-2021年全球、地区和国家男性乳腺癌负担：2021年全球疾病负担研究的系统分析

背景：由于男性参与有限，男性乳腺癌（MBC）是罕见的，通常使用女性乳腺癌（BC）试验的证据进行治疗。以前的估计缺乏全球覆盖和完整性。我们旨在量化1990年至2021年全球MBC负担，并评估其现状和趋势。方法：基于全球疾病负担（GBD）数据库，我们收集并分析了MBC的发病率、死亡率和残疾调整生命年（DALYs）的数据，并使用年龄标准化率（ASRs）作为这些测量的指标。我们的研究计算了估计的年度百分比变化（EAPC），旨在测量asr的平均变化。此外，我们评估了全球不同地区和年龄组MBC的归因风险因素（rf）和趋势。结果：2021年，全球每10万人MBC年龄标准化发病率（ASIR）、年龄标准化死亡率（ASDR）和年龄标准化DALY （ASDALY）分别为0.941 （95% UI, 0.605-1.155）、0.335 （95% UI, 0.232-0.409）和9.157 （95% UI, 6.116-11.423）。与1990年相比，这些比率分别增加了2.212 （95% UI, 2.047 ~ 2.378）、0.664 （95% UI, 0.562 ~ 0.767）和0.853 （95% UI, 0.750 ~ 0.956）。在乌干达2021年，MBC的ASIR和ASDR最高，分别为4.541 （95% UI, 3.028 ~ 6.808）和3.510 (95% UI, 2.301 ~ 5.195) / 10万人。MBC的负担随年龄的增长而增加。在全球范围内，饮食风险是导致MBC死亡的最重要的可归因RF，死亡率为11.690% (95% UI, -0.003%-24.838%)，其次是饮酒和吸烟。结论：1990 - 2021年，MBC的ASIR、ASDR、ASDALY均存在显著差异，且呈上升趋势。选择健康的生活方式，如减少烟酒消费和积极改变饮食习惯，可有助于降低MBC风险。制定和执行强有力和有效的公共卫生政策对于减轻全球疾病负担至关重要。

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来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.