The CT findings of extranodal natural killer/T-cell lymphoma, nasal type involving the gastrointestinal tract.

IF 4.7 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING European Radiology Pub Date : 2025-08-01 Epub Date: 2025-01-29 DOI:10.1007/s00330-025-11369-8

Yi Sun, Hailing Liu, Peiyi Xie, Pan Zhu, Xiaochun Meng

{"title":"The CT findings of extranodal natural killer/T-cell lymphoma, nasal type involving the gastrointestinal tract.","authors":"Yi Sun, Hailing Liu, Peiyi Xie, Pan Zhu, Xiaochun Meng","doi":"10.1007/s00330-025-11369-8","DOIUrl":null,"url":null,"abstract":"Objectives: To analyze the CT imaging features of extranodal natural killer/T (NK/T)-cell lymphoma, nasal type (ENKTCL-NT) involving the gastrointestinal tract (GI), and to compare them with those of Crohn's disease (CD) and diffuse large B-cell lymphoma (DLBCL).Materials and methods: Data were retrospectively collected from 17 patients diagnosed with GI ENKTCL-NT, 68 patients with CD, and 47 patients with DLBCL. The CT findings of ENKTCL-NT were analyzed and compared with those of CD and DLBCL. Data were analyzed using SPSS (version 25.0) and MedCalc (version 18.2.1). p < 0.05 was considered statistically significant.Results: The 17 patients with ENKTCL-NT included 11 males (64.7%) and 6 females (35.3%) (mean age, 46.41 ± 4.12 years). The CT features of ENKTCL-NT included: circumferential symmetric thickening (100%), moderate thickening (70.6%), skip lesions (52.9%), contiguous lesion (47.1%), mucosal or layered enhancement (70.6%), moderate mural enhancement (64.7%) with non-enhanced regions (47.1%), absence of lymphadenopathy (76.5%), bowel perforation or fistula (17.6%), and peri-enteric blurred fat space (70.6%). The presence of circumferential symmetric thickening, moderate mural enhancement, and non-enhanced regions were more indicative of ENKTCL-NT than CD (17/17 vs. 17/68, 11/17 vs. 22/68, 8/17 vs. 0/68, p < 0.05). The presence of skip lesions, mucosal or layered enhancement, and absence of peri-enteric lymphadenopathy were more indicative of ENKTCL-NT than DLBCL (9/17 vs. 2/47, 12/17 vs. 1/37, 13/17 vs. 19/47, p < 0.05).Conclusion: CT imaging features can provide useful information for the early diagnosis of ENKTCL-NT and effectively differentiate it from CD and DLBCL.Key points: Question Extranodal natural killer/T-cell lymphoma, nasal type (ENKTCL-NT) involving the gastrointestinal tract (GI) is highly malignant but easily misdiagnosed by clinicians and endoscopic examination. Findings CT could provide useful information in the diagnosis of ENKTCL-NT involving GI and in differentiating it from Crohn's disease and diffuse large B-cell lymphoma. Clinical relevance This study will help improve the ability of radiologists to diagnose ENKTCL-NT involving GI, and a more predictive diagnosis will also alert clinicians to perform multiple deep endoscopic biopsies, which will contribute to the early diagnosis and treatment of ENKTCL-NT.","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"4932-4944"},"PeriodicalIF":4.7000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00330-025-11369-8","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/29 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: To analyze the CT imaging features of extranodal natural killer/T (NK/T)-cell lymphoma, nasal type (ENKTCL-NT) involving the gastrointestinal tract (GI), and to compare them with those of Crohn's disease (CD) and diffuse large B-cell lymphoma (DLBCL).

Materials and methods: Data were retrospectively collected from 17 patients diagnosed with GI ENKTCL-NT, 68 patients with CD, and 47 patients with DLBCL. The CT findings of ENKTCL-NT were analyzed and compared with those of CD and DLBCL. Data were analyzed using SPSS (version 25.0) and MedCalc (version 18.2.1). p < 0.05 was considered statistically significant.

Results: The 17 patients with ENKTCL-NT included 11 males (64.7%) and 6 females (35.3%) (mean age, 46.41 ± 4.12 years). The CT features of ENKTCL-NT included: circumferential symmetric thickening (100%), moderate thickening (70.6%), skip lesions (52.9%), contiguous lesion (47.1%), mucosal or layered enhancement (70.6%), moderate mural enhancement (64.7%) with non-enhanced regions (47.1%), absence of lymphadenopathy (76.5%), bowel perforation or fistula (17.6%), and peri-enteric blurred fat space (70.6%). The presence of circumferential symmetric thickening, moderate mural enhancement, and non-enhanced regions were more indicative of ENKTCL-NT than CD (17/17 vs. 17/68, 11/17 vs. 22/68, 8/17 vs. 0/68, p < 0.05). The presence of skip lesions, mucosal or layered enhancement, and absence of peri-enteric lymphadenopathy were more indicative of ENKTCL-NT than DLBCL (9/17 vs. 2/47, 12/17 vs. 1/37, 13/17 vs. 19/47, p < 0.05).

Conclusion: CT imaging features can provide useful information for the early diagnosis of ENKTCL-NT and effectively differentiate it from CD and DLBCL.

Key points: Question Extranodal natural killer/T-cell lymphoma, nasal type (ENKTCL-NT) involving the gastrointestinal tract (GI) is highly malignant but easily misdiagnosed by clinicians and endoscopic examination. Findings CT could provide useful information in the diagnosis of ENKTCL-NT involving GI and in differentiating it from Crohn's disease and diffuse large B-cell lymphoma. Clinical relevance This study will help improve the ability of radiologists to diagnose ENKTCL-NT involving GI, and a more predictive diagnosis will also alert clinicians to perform multiple deep endoscopic biopsies, which will contribute to the early diagnosis and treatment of ENKTCL-NT.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

结外自然杀伤/ t细胞淋巴瘤，鼻型，累及胃肠道。

目的：分析结外自然杀伤/T （NK/T）细胞型鼻型淋巴瘤（ENKTCL-NT）累及胃肠道（GI）的CT表现特点，并与克罗恩病（CD）和弥漫性大b细胞淋巴瘤（DLBCL）的CT表现进行比较。材料和方法：回顾性收集17例GI ENKTCL-NT患者、68例CD患者和47例DLBCL患者的资料。分析ENKTCL-NT的CT表现，并与CD、DLBCL进行比较。采用SPSS（25.0版本）和MedCalc（18.2.1版本）对数据进行分析。结果：17例ENKTCL-NT患者中男性11例（64.7%），女性6例（35.3%），平均年龄46.41±4.12岁。ENKTCL-NT的CT表现包括：环周对称增厚（100%）、中度增厚（70.6%）、跳跃性病变（52.9%）、连续性病变（47.1%）、粘膜或层状增强（70.6%）、中度壁增强（64.7%）伴非增强区（47.1%）、无淋巴结病变（76.5%）、肠穿孔或瘘（17.6%）、肠周脂肪间隙模糊（70.6%）。围周对称增厚、中度壁强化、非强化区较CD更能提示ENKTCL-NT (17/17 vs. 17/68, 11/17 vs. 22/68, 8/17 vs. 0/68， p结论：CT影像特征可为ENKTCL-NT的早期诊断提供有用信息，可有效与CD、DLBCL鉴别。结外自然杀伤/鼻型t细胞淋巴瘤（ENKTCL-NT）是一种累及胃肠道的恶性淋巴瘤，但极易被临床医生和内镜检查误诊。结果CT对ENKTCL-NT累及胃肠道的诊断及与克罗恩病、弥漫性大b细胞淋巴瘤的鉴别诊断有重要价值。本研究将有助于提高放射科医生诊断涉及胃肠道的ENKTCL-NT的能力，更具预测性的诊断也将提醒临床医生进行多次深部内镜活检，这将有助于ENKTCL-NT的早期诊断和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

European Radiology 医学-核医学

CiteScore

11.60

自引率

8.50%

发文量

874

审稿时长

2-4 weeks

期刊介绍： European Radiology (ER) continuously updates scientific knowledge in radiology by publication of strong original articles and state-of-the-art reviews written by leading radiologists. A well balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes ER an indispensable source for current information in this field. This is the Journal of the European Society of Radiology, and the official journal of a number of societies. From 2004-2008 supplements to European Radiology were published under its companion, European Radiology Supplements, ISSN 1613-3749.