Quantitative Plaque Characteristics/Pericoronary Fat Attenuation Index and Acute Coronary Syndrome in Patients With Stable Angina Pectoris.

IF 1.3 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Journal of Computer Assisted Tomography Pub Date : 2025-07-01 Epub Date: 2025-01-27 DOI:10.1097/RCT.0000000000001718

Defu Li, Yujin Wang, Tingting Zhu

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Abstract

Objective: Vascular inflammation affects acute coronary syndrome (ACS) occurrence in patients with stable angina. Coronary inflammation can be represented by the pericoronary fat attenuation index (FAI).This study investigated the quantitative prognostic value of plaque characteristics and FAI in patients with stable angina.

Methods: Risk factors for ACS occurrence in patients with stable angina pectoris were retrospectively analyzed. The diagnostic value of FAI and plaque characteristics for ACS occurrence in these patients were determined; Kaplan-Meier curves were used to predict ACS event incidence.

Results: After postpropensity score matching, data of 60 and 130 patients with and without ACS, respectively, were analyzed. Pericoronary FAI, lipid volume, and lipid percentage in the narrowest segment significantly improved ACS diagnosis in patients with stable angina. Luminal stenosis ≥50% and FAI >-88 Hounsfield units (HU) were independent risk factors for ACS occurrence in patients with stable angina. Perileft anterior descending artery (LAD) FAI >-88 HU better predicted ACS occurrence in patients with stable angina than did peri-LAD FAI ≤-88 HU.

Conclusions: In patients with stable angina, lipid volume and percentage and pericoronary FAI improved the diagnostic ability of luminal stenosis for ACS occurrence. Furthermore, peri-LAD FAI >-88 HU could predict ACS occurrence.

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稳定型心绞痛患者定量斑块特征/冠状动脉脂肪衰减指数与急性冠脉综合征

目的：血管炎症影响稳定型心绞痛患者急性冠脉综合征（ACS）的发生。冠状动脉炎症可以用冠状动脉脂肪衰减指数（FAI）来表示。本研究探讨斑块特征和FAI在稳定型心绞痛患者中的定量预后价值。方法：回顾性分析稳定型心绞痛患者发生ACS的危险因素。确定FAI和斑块特征对这些患者ACS发生的诊断价值；Kaplan-Meier曲线用于预测ACS事件发生率。结果：经倾向后评分匹配，分别分析60例和130例ACS患者和非ACS患者的数据。冠状动脉周围FAI、最窄段脂质体积和脂质百分比可显著提高稳定型心绞痛患者的ACS诊断。管腔狭窄≥50%、FAI≥≥88 Hounsfield单位（HU）是稳定型心绞痛患者发生ACS的独立危险因素。与左前降支周围FAI≤-88 HU相比，左前降支周围FAI≤-88 HU更能预测稳定型心绞痛患者ACS的发生。结论：在稳定型心绞痛患者中，脂质体积和脂质百分比以及冠状动脉周围FAI可提高对ACS发生的管腔狭窄的诊断能力。此外，lad周围FAI b> - 88hu可预测ACS的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Computer Assisted Tomography 医学-核医学

CiteScore

2.50

自引率

0.00%

发文量

230

审稿时长

4-8 weeks

期刊介绍： The mission of Journal of Computer Assisted Tomography is to showcase the latest clinical and research developments in CT, MR, and closely related diagnostic techniques. We encourage submission of both original research and review articles that have immediate or promissory clinical applications. Topics of special interest include: 1) functional MR and CT of the brain and body; 2) advanced/innovative MRI techniques (diffusion, perfusion, rapid scanning); and 3) advanced/innovative CT techniques (perfusion, multi-energy, dose-reduction, and processing).