Pyrroloquinoline quinone-loaded coaxial nanofibers prevent oxidative stress after spinal cord injury.

IF 4.6 3区材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY Nanoscale Advances Pub Date : 2025-01-09 DOI:10.1039/d4na00885e

Sara Ibrahim, Mohammed Ismail, Taghrid Abdelrahman, Mona Sharkawy, Ahmed Abdellatif, Nageh K Allam

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Abstract

Oxidative stress plays a major role in the secondary injury of the spinal cord tissue due to the high lipid content of nervous tissue. In the present study, coaxial nanofibers were loaded with the natural antioxidant pyrroloquinoline quinone (PQQ) and used as an implantable drug-delivery system and a scaffold post-SCI. The obtained data show that the concentration of NO and the activity of inducible nitric oxide synthase (iNOS) were significantly (P < 0.05) increased in the spinal cord injury (SCI) group. These levels were significantly decreased following treatment with nanofibers/PQQ. Implantation of nanofibers/PQQ resulted in a significant (P < 0.05) drop in the level of malondialdehyde (MDA) compared to the SCI group. The application of nanofibers loaded with PQQ after SCI caused a significant (P < 0.05) elevation of superoxide dismutase (SOD) and catalase (CAT) activity in the spinal cord tissue. The present work shows the protective role of coaxial nanofibers loaded with PQQ against oxidative stress in spinal cord injury. The reversal of oxidative stress with PQQ can lead to better outcomes following spinal cord injury.

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