IGF2BP3 is upregulated in endometrial cancer and tightly regulates the growth of drug-resistant endometrial cancer cells via HMGA1.

IF 2.9 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Science Progress Pub Date : 2025-01-01 DOI:10.1177/00368504251315008

Yiwei Zhang, Yanlai Xiao, Xiangzhai Zhao, Jie Xu, Huan Zhao, Zhaojun Guo, Jun Zhao, Yajing Zhang, Ruoxi Wang, Jian Wang

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Abstract

Objective: Endometrial cancer (EC) is a malignant tumor with various histological subtypes and molecular phenotypes. The evaluation of drug resistance is important for cancer treatment. Progesterone resistance is the major challenge in EC. Knowledge of drug resistance in EC is important in the development of novel therapies.

Methods: In this study, ten paracancerous and ten tumor tissues were collected to measure the expression of insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) and high-mobility group protein 1 (HMGA1). AN3CA and Ishikawa cells were used to explore the effects of IGF2BP3 on EC.

Results: The expression levels of IGF2BP3 and HMGA1 were higher in EC tumor tissues than in paracancerous tissues. IGF2BP3 and HMGA1 are highly expressed in cisplatin-resistant EC cells. IGF2BP3 knockdown decreased the growth of cisplatin-resistant EC cells. Knockdown of IGF2BP3 decreased the level of HMGA1 protein. HMGA1 knockdown decreased the growth of cisplatin-resistant EC cells.

Discuss and conclusions: The findings demonstrate that IGF2BP3 is upregulated in EC and closely regulates the growth of drug-resistant EC cells via HMGA1. The findings will inform the development of novel therapies for EC.

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IGF2BP3在子宫内膜癌中表达上调，并通过HMGA1紧密调控耐药子宫内膜癌细胞的生长。

目的：子宫内膜癌（EC）是一种具有多种组织学亚型和分子表型的恶性肿瘤。耐药评价对肿瘤治疗具有重要意义。黄体酮耐药性是EC的主要挑战。了解EC的耐药性对开发新的治疗方法非常重要。方法：本研究收集10例癌旁组织和10例肿瘤组织，检测胰岛素样生长因子2 mRNA结合蛋白3 （IGF2BP3）和高迁移率组蛋白1 （HMGA1）的表达。采用AN3CA和Ishikawa细胞研究IGF2BP3对EC的影响。结果：IGF2BP3和HMGA1在EC肿瘤组织中的表达水平高于癌旁组织。IGF2BP3和HMGA1在顺铂耐药EC细胞中高表达。IGF2BP3敲低可抑制顺铂耐药EC细胞的生长。IGF2BP3基因敲低可降低HMGA1蛋白水平。HMGA1敲低可抑制顺铂耐药EC细胞的生长。讨论与结论：研究结果表明IGF2BP3在EC中表达上调，并通过HMGA1密切调控EC耐药细胞的生长。这一发现将为EC的新疗法的发展提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Progress Multidisciplinary-Multidisciplinary

CiteScore

3.80

自引率

0.00%

发文量

119

期刊介绍： Science Progress has for over 100 years been a highly regarded review publication in science, technology and medicine. Its objective is to excite the readers'' interest in areas with which they may not be fully familiar but which could facilitate their interest, or even activity, in a cognate field.