Optic Disc Pallor in Parkinson's Disease: A UK Biobank Study

IF 7.6 1区医学 Q1 CLINICAL NEUROLOGY Movement Disorders Pub Date : 2025-01-30 DOI:10.1002/mds.30127

Samuel Gibbon MSc, David P. Breen MBChB, PhD, Thomas J. MacGillivray PhD, UK Biobank Eye & Vision Consortium

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Abstract

Background

Recent studies have suggested that retinal changes measured with optical coherence tomography are detectable in early Parkinson's disease (PD), highlighting the potential of ophthalmic biomarkers for diagnosis and monitoring.

Objective

We set out to investigate the relationship between optic disc pallor measured in fundoscopy images and both prevalent and incident PD.

Methods

We analyzed color fundus photographs from 787 UK Biobank participants: 89 with prevalent PD, 317 with incident PD, and 381 age- and sex-matched controls. Optic disc pallor in several zones was quantified using semi-automated software. We used logistic and linear regression, adjusted for relevant covariates, to test for associations between disc pallor and PD status and duration.

Results

Participants with prevalent PD had significantly paler optic discs globally (OR per standard deviation [SD] increase = 1.39 [CI: 1.08–1.81], P = 0.012) and across several zones compared to controls. Each year since PD diagnosis was associated with a 1.37 SD increase in global pallor (standardized β = 1.37 [SE = 0.61], P = 0.029), and a similar increase across several zones, however, this finding was sensitive to outliers with long disease duration. No significant associations were observed for the incident PD group.

Conclusions

Optic disc pallor is significantly associated with PD and may become more pronounced with disease duration. This suggests that optic disc pallor, measured in routinely taken color fundus photographs, may serve as a biomarker for PD-related neurodegeneration. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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帕金森病视盘苍白：一项英国生物库研究。

背景：最近的研究表明，光学相干断层扫描测量的视网膜变化可以在早期帕金森病（PD）中检测到，这突出了眼科生物标志物在诊断和监测方面的潜力。目的：探讨眼底镜检图像中视盘苍白度与PD患病率和发生率的关系。方法：我们分析了787名英国生物银行参与者的彩色眼底照片：89名常见病患者，317名发病患者，381名年龄和性别匹配的对照组。用半自动化软件对几个区域的视盘苍白度进行量化。我们使用逻辑回归和线性回归，调整相关协变量，来检验椎间盘苍白与PD状态和持续时间之间的关联。结果：与对照组相比，患有普遍PD的参与者的视盘整体（OR每标准差[SD]增加= 1.39 [CI: 1.08-1.81], P = 0.012）和多个区域的视盘明显变白。自PD诊断以来，每年总体苍白度增加1.37 SD（标准化β = 1.37 [SE = 0.61], P = 0.029），并且在几个区域中也有类似的增加，然而，这一发现对病程长的异常值很敏感。在偶发PD组中没有观察到明显的关联。结论：视盘苍白与PD显著相关，随着病程的延长可能变得更加明显。这表明视盘苍白，常规拍摄彩色眼底照片测量，可能作为pd相关神经变性的生物标志物。©2025作者。Wiley期刊有限责任公司代表国际帕金森和运动障碍学会出版的《运动障碍》。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.