Effect of panretinal photocoagulation on retinal oxygen metabolism and ocular blood flow in diabetic retinopathy

IF 2.8 3区医学 Q1 OPHTHALMOLOGY Acta Ophthalmologica Pub Date : 2025-01-30 DOI:10.1111/aos.17442

Ahmed M. Abu El-Asrar, Waleed K. Alsarhani, Abdulrahman F. AlBloushi, Abdullah Alzubaidi, Priscilla Gikandi, Einar Stefánsson

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Abstract

Purpose

To investigate the effects of panretinal photocoagulation (PRP) on retinal oxygen metabolism, calibre of retinal vessels, and blood flow velocity in the optic nerve head (ONH) and choroid in patients with severe nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR).

Methods

In this retrospective study, 37 patients (37 eyes) were studied. Retinal oximetry and laser speckle flowgraphy measurements were performed at baseline and after PRP.

Results

After PRP, oxygen saturation of retinal arterioles (p = 0.003) and arteriovenous oxygen saturation difference (p = 0.005) significantly increased. On the other hand, the calibre of retinal arterioles significantly decreased (p = 0.016). In the ONH, mean blur rate (MBR)-vessel (p = 0.002), representing blood flow velocity in the retinal vessels, and MBR-tissue (p = 0.002), representing ONH blood flow velocity, and choroidal MBR (p = 0.012) significantly decreased. At baseline, there were significant negative correlations between ONH MBR-overall (r = −0.382, p = 0.026) and ONH MBR-tissue (r = −0.455, p = 0.007) and arteriovenous oxygen saturation difference. After PRP, choroidal MBR had a significant negative correlation with arteriolar oxygen saturation (r = −0.415, p = 0.016).

Conclusions

The effects of PRP are correlated with increased arteriovenous oxygen saturation difference, reduction in the calibre of retinal arterioles, and reduction of retinal and choroidal blood flow velocities.

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全视网膜光凝对糖尿病视网膜病变视网膜氧代谢及眼血流的影响。

目的：探讨全视网膜光凝治疗（PRP）对重度非增殖性糖尿病视网膜病变（NPDR）和增殖性糖尿病视网膜病变（PDR）患者视网膜氧代谢、视网膜血管直径、视神经头（ONH）及脉络膜血流速度的影响。方法：对37例患者（37只眼）进行回顾性研究。视网膜血氧仪和激光散斑血流仪测量在基线和PRP后进行。结果：PRP后视网膜小动脉血氧饱和度（p = 0.003）和动静脉血氧饱和度差（p = 0.005）显著升高。另一方面，视网膜小动脉直径明显减小（p = 0.016）。在ONH中，平均模糊率(MBR)-血管（p = 0.002）代表视网膜血管血流速度，MBR-组织（p = 0.002）代表ONH血流速度，脉络膜MBR （p = 0.012）显著降低。基线时，ONH MBR-overall （r = -0.382, p = 0.026）和ONH MBR-tissue （r = -0.455, p = 0.007）与动静脉血氧饱和度差呈显著负相关。PRP后脉络膜MBR与动脉氧饱和度呈显著负相关（r = -0.415, p = 0.016）。结论：PRP的作用与动静脉血氧饱和度差升高、视网膜小动脉直径减小、视网膜和脉络膜血流速度降低有关。

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来源期刊

Acta Ophthalmologica 医学-眼科学

CiteScore

7.60

自引率

5.90%

发文量

433

审稿时长

6 months

期刊介绍： Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.