George R Thompson, Gelina M Sani, Monica A Donnelley, Jaimie K Figueroa, Ryan Ciuffetelli, Kate Trigg, Juan Arredondo, Alan Koff, Marie Nearing, Ikaika C Loque, Derek J Bays, Satya Dandekar
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引用次数: 0
Abstract
Infusion reactions (tachycardia, hypertension, fever, etc.) associated with liposomal amphotericin B are common. Animal models have found complement activation responsible, yet the pathophysiology has not been evaluated in human patients. We performed a prospective observational study and found complement activation-related pseudoallergy (CARPA) responsible in those with infusion reactions.
期刊介绍：
Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.
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