SLC26A9 promotes the initiation and progression of breast cancer by activating the PI3K/AKT signaling pathway

IF 4.6 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et biophysica acta. Molecular cell research Pub Date : 2025-01-27 DOI:10.1016/j.bbamcr.2025.119912

Zhiyuan Ma , Hu Wang , Zhengxing Zhou , Chengli Lu , Minglin Zhang , Renmin Mu , Chengmin Zhang , Zhiqiang Yi , Zilin Deng , Yingying Zhao , Jiaxing Zhu , Guorong Wen , Hai Jin , Jiaxing An , Biguang Tuo , Peng Yuan , Xuemei Liu , Taolang Li

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引用次数: 0

Abstract

SLC26A9 is a member of the Slc26a family of multifunctional anion transporters that function as Cl⁻ channels in the stomach. We reported for the first time that SLC26A9 is involved in gastric tumorigenesis. However, the role of SLC26A9 in breast cancer has not yet been investigated. We first demonstrated that the upregulation of SLC26A9 is associated with the clinicopathological progression and poor prognosis of patients with breast cancer and is positively correlated with HER2 amplification. SLC26A9 alters the proliferation, migration, and invasion potential of breast cancer cells by regulating the PI3K/AKT signaling pathway. SLC26A9 acts as an oncogene in the development of breast cancer. These findings provide valuable insights for the development of future diagnostic and therapeutic strategies for BC.

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来源期刊

Biochimica et biophysica acta. Molecular cell research 生物-生化与分子生物学

CiteScore

10.00

自引率

2.00%

发文量

151

审稿时长

44 days

期刊介绍： BBA Molecular Cell Research focuses on understanding the mechanisms of cellular processes at the molecular level. These include aspects of cellular signaling, signal transduction, cell cycle, apoptosis, intracellular trafficking, secretory and endocytic pathways, biogenesis of cell organelles, cytoskeletal structures, cellular interactions, cell/tissue differentiation and cellular enzymology. Also included are studies at the interface between Cell Biology and Biophysics which apply for example novel imaging methods for characterizing cellular processes.