SLC26A9 promotes the initiation and progression of breast cancer by activating the PI3K/AKT signaling pathway

IF 3.7 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et biophysica acta. Molecular cell research Pub Date : 2025-03-01 Epub Date: 2025-01-27 DOI:10.1016/j.bbamcr.2025.119912

Zhiyuan Ma , Hu Wang , Zhengxing Zhou , Chengli Lu , Minglin Zhang , Renmin Mu , Chengmin Zhang , Zhiqiang Yi , Zilin Deng , Yingying Zhao , Jiaxing Zhu , Guorong Wen , Hai Jin , Jiaxing An , Biguang Tuo , Peng Yuan , Xuemei Liu , Taolang Li

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引用次数: 0

Abstract

SLC26A9 is a member of the Slc26a family of multifunctional anion transporters that function as Cl⁻ channels in the stomach. We reported for the first time that SLC26A9 is involved in gastric tumorigenesis. However, the role of SLC26A9 in breast cancer has not yet been investigated. We first demonstrated that the upregulation of SLC26A9 is associated with the clinicopathological progression and poor prognosis of patients with breast cancer and is positively correlated with HER2 amplification. SLC26A9 alters the proliferation, migration, and invasion potential of breast cancer cells by regulating the PI3K/AKT signaling pathway. SLC26A9 acts as an oncogene in the development of breast cancer. These findings provide valuable insights for the development of future diagnostic and therapeutic strategies for BC.

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SLC26A9通过激活PI3K/AKT信号通路促进乳腺癌的发生和发展。

SLC26A9是Slc26a家族多功能阴离子转运体的一员，在胃中起Cl-通道的作用。我们首次报道了SLC26A9参与胃肿瘤的发生。然而，SLC26A9在乳腺癌中的作用尚未被研究。我们首先证明了SLC26A9的上调与乳腺癌患者的临床病理进展和预后不良相关，并与HER2扩增呈正相关。SLC26A9通过调控PI3K/AKT信号通路改变乳腺癌细胞的增殖、迁移和侵袭潜能。SLC26A9在乳腺癌的发展中起致癌基因的作用。这些发现为未来BC的诊断和治疗策略的发展提供了有价值的见解。

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来源期刊

Biochimica et biophysica acta. Molecular cell research 生物-生化与分子生物学

CiteScore

10.00

自引率

2.00%

发文量

151

审稿时长

44 days

期刊介绍： BBA Molecular Cell Research focuses on understanding the mechanisms of cellular processes at the molecular level. These include aspects of cellular signaling, signal transduction, cell cycle, apoptosis, intracellular trafficking, secretory and endocytic pathways, biogenesis of cell organelles, cytoskeletal structures, cellular interactions, cell/tissue differentiation and cellular enzymology. Also included are studies at the interface between Cell Biology and Biophysics which apply for example novel imaging methods for characterizing cellular processes.