The Association Between Adiponectin Gene Polymorphism (rs1501299) and Metabolic Syndrome.

IF 3 3区医学 Q3 ENDOCRINOLOGY & METABOLISM Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2025-01-25 eCollection Date: 2025-01-01 DOI:10.2147/DMSO.S475193

Lianli Yin, Yinghua Tang, Yulin Yuan

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Abstract

Objective: To investigate the allelic genotypes of the adiponectin (APN) gene polymorphisms (rs1501299) and its association with APN level among Mets patients.

Methods: A total of 410 patients with Mets and 203 healthy subjects were included in the study. The serum APN levels of the subjects were detected using enzyme-linked immunosorbent assay. The polymorphisms of the G/T gene at the rs1501299 locus of the APN gene were detected using restriction fragment length polymorphism polymerase chain reaction technology.

Results: The serum APN levels were significantly lower in Mets patients than in the control group (15.0 ± 4.9 mg/L vs 27.2 ± 6.5 mg/L, p < 0.05). The distribution of the three genotypes at the rs1501299 locus was statistically different between the Mets patients and the control group (GG, GT, and TT, p < 0.05), and the frequencies of the T alleles were higher in the Mets patients than in control group (GT and TT, p < 0.05). Logistic regression analysis showed that the study subjects with the T allele had a higher risk of Mets than those with the G allele (OR = 1.85, p < 0.05). The risk of Mets was higher in GT and TT genotypes compared to in GG genotypes (OR = 1.43; OR = 2.14 vs OR = 1.00 ref). Similarly, it increased after combining GT and GG genotypes (OR = 1.73, p < 0.05). The APN levels in the GT (14.3 ± 5.3 mg/L) and TT (13.4 ± 5.4 mg/L) genotypes of the study subjects were lower than those of the GG genotype (15.5 ± 4.8 mg/L, p < 0.05).

Conclusion: The occurrence of Mets may be associated with genetic variants at the rs1501299 locus, especially for individuals with G to T variants that reduce APN levels and lead to a higher risk of developing Mets.

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脂联素基因多态性与代谢综合征的关系

目的：探讨代谢综合征患者脂联素（APN）基因多态性rs1501299等位基因型及其与APN水平的关系。方法：共纳入410例Mets患者和203名健康受试者。采用酶联免疫吸附法检测受试者血清APN水平。采用限制性内切片段长度多态性聚合酶链反应技术检测APN基因rs1501299位点G/T基因多态性。结果：met患者血清APN水平显著低于对照组（15.0±4.9 mg/L vs 27.2±6.5 mg/L, p < 0.05）。rs1501299位点3个基因型的分布在met患者与对照组之间有统计学差异（GG、GT、TT, p < 0.05），且met患者中T等位基因频率高于对照组（GT、TT, p < 0.05）。Logistic回归分析显示，携带T等位基因的受试者发生Mets的风险高于携带G等位基因的受试者（OR = 1.85, p < 0.05）。GT和TT基因型的met风险高于GG基因型(OR = 1.43；OR = 2.14 vs OR = 1.00 ref)。GT基因型与GG基因型联合使用后，其差异有统计学意义（OR = 1.73, p < 0.05）。GT基因型（14.3±5.3 mg/L）和TT基因型（13.4±5.4 mg/L） APN水平低于GG基因型（15.5±4.8 mg/L, p < 0.05）。结论：Mets的发生可能与rs1501299位点的遗传变异有关，特别是对于具有G to T变异的个体，这种变异降低了APN水平，导致发生Mets的风险更高。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.