Effect of acupuncture on the gait disturbance and hemodynamic changes in the prefrontal cortex: a study protocol for a randomized controlled trial.

IF 2.8 3区医学 Q2 CLINICAL NEUROLOGY Frontiers in Neurology Pub Date : 2025-01-15 eCollection Date: 2024-01-01 DOI:10.3389/fneur.2024.1444873

Zhenmei Hong, Shuijing Zhang, Shuqing Zhang, Yuqi Zhao, Xiancong Ye, Xinxin Shu, Yufan Chen, Shuding Yan, Ruijie Ma

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Abstract

Background: Alzheimer's disease (AD) is characterized by cognitive impairment and behavioral impairment. The gait of AD patients is attracting the increasing attention. The aim of this randomized controlled trial (RCT) is to explore the effect of acupuncture on the cognitive function, gait performance, and hemodynamic changes in the prefrontal cortices.

Methods: In this RCT, a total of 108 AD patients will be randomly assigned into acupuncture group or control group for 8 weeks. The primary outcome will be three-dimensional gait analysis and cerebral hemodynamics using functional near-infrared spectroscopy (fNIRS). Secondary outcomes will include Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Barthel Index (BI).

Discussion: This trial is expected to explore the effect of acupuncture on cognitive function, gait performance, and hemodynamic changes in the prefrontal cortices for AD patients.

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针刺对步态障碍和前额皮质血流动力学改变的影响：一项随机对照试验的研究方案。

背景：阿尔茨海默病（AD）以认知障碍和行为障碍为特征。AD患者的步态越来越受到人们的关注。本随机对照试验（RCT）的目的是探讨针刺对认知功能、步态表现和前额叶皮层血流动力学变化的影响。方法：将108例AD患者随机分为针刺组和对照组，疗程为 周。主要结果将是使用功能近红外光谱（fNIRS）进行三维步态分析和脑血流动力学。次要结果将包括迷你精神状态检查（MMSE）、蒙特利尔认知评估（MoCA）和Barthel指数（BI）。讨论：本试验旨在探讨针灸对AD患者认知功能、步态表现和前额皮质血流动力学变化的影响。

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来源期刊

Frontiers in Neurology CLINICAL NEUROLOGYNEUROSCIENCES -NEUROSCIENCES

CiteScore

4.90

自引率

8.80%

发文量

2792

审稿时长

14 weeks

期刊介绍： The section Stroke aims to quickly and accurately publish important experimental, translational and clinical studies, and reviews that contribute to the knowledge of stroke, its causes, manifestations, diagnosis, and management.