Cellular and humoral immune responses in cats vaccinated with feline herpesvirus 1 modified live virus vaccine.

IF 2.9 2区农林科学 Q1 VETERINARY SCIENCES Frontiers in Veterinary Science Pub Date : 2025-01-15 eCollection Date: 2024-01-01 DOI:10.3389/fvets.2024.1516850

Hongchao Wu, Peipei Qiao, Yunyu Chen, Caihong Liu, Ningning Huo, Hangtian Ding, Xiaojuan Wang, Lulu Wang, Xiangfeng Xi, Yuxiu Liu, Kegong Tian

{"title":"Cellular and humoral immune responses in cats vaccinated with feline herpesvirus 1 modified live virus vaccine.","authors":"Hongchao Wu, Peipei Qiao, Yunyu Chen, Caihong Liu, Ningning Huo, Hangtian Ding, Xiaojuan Wang, Lulu Wang, Xiangfeng Xi, Yuxiu Liu, Kegong Tian","doi":"10.3389/fvets.2024.1516850","DOIUrl":null,"url":null,"abstract":"<p><p>Feline herpesvirus 1 (FHV-1) is an important pathogen causing infectious rhinotracheitis in felids, mainly infecting the upper respiratory tract and conjunctiva. Multiple vaccines are available to prevent FHV-1 infection, and the antibody levels are always used to evaluate their effectiveness. However, the cellular immunity response following immunization in cats remains unclear. This study investigated the immune responses (humoral and cellular) in cats immunized with the FHV-1 modified live virus vaccine. The results indicated that vaccination significantly reduced clinical signs, and antibody levels, including virus-neutralizing (VN) antibodies and immunoglobulin G (IgG), in the vaccine group were higher than those in the control groups. Additionally, the vaccine significantly increased cytokine secretion, indicating Th1-type cellular immune responses in cats. Moreover, cellular immune-related indicators, such as CD8+ T cells, CD4+ T cells, and interferon-gamma levels, were inversely correlated with clinical signs post-challenge by FHV-1 in vaccinated cats, highlighting its crucial role in protecting cats against FHV-1 infection. In summary, this study demonstrated the importance of cellular immune responses in protecting cats from FHV-1 infection after vaccination.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"11 ","pages":"1516850"},"PeriodicalIF":2.9000,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775014/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Veterinary Science","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3389/fvets.2024.1516850","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Feline herpesvirus 1 (FHV-1) is an important pathogen causing infectious rhinotracheitis in felids, mainly infecting the upper respiratory tract and conjunctiva. Multiple vaccines are available to prevent FHV-1 infection, and the antibody levels are always used to evaluate their effectiveness. However, the cellular immunity response following immunization in cats remains unclear. This study investigated the immune responses (humoral and cellular) in cats immunized with the FHV-1 modified live virus vaccine. The results indicated that vaccination significantly reduced clinical signs, and antibody levels, including virus-neutralizing (VN) antibodies and immunoglobulin G (IgG), in the vaccine group were higher than those in the control groups. Additionally, the vaccine significantly increased cytokine secretion, indicating Th1-type cellular immune responses in cats. Moreover, cellular immune-related indicators, such as CD8+ T cells, CD4+ T cells, and interferon-gamma levels, were inversely correlated with clinical signs post-challenge by FHV-1 in vaccinated cats, highlighting its crucial role in protecting cats against FHV-1 infection. In summary, this study demonstrated the importance of cellular immune responses in protecting cats from FHV-1 infection after vaccination.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

猫疱疹病毒1型修饰活病毒疫苗免疫后的细胞和体液免疫反应

猫疱疹病毒1型（FHV-1）是引起猫科动物传染性鼻气管炎的重要病原体，主要感染上呼吸道和结膜。有多种疫苗可用于预防FHV-1感染，抗体水平总是用于评估其有效性。然而，猫免疫后的细胞免疫反应尚不清楚。本研究研究了猫接种FHV-1修饰活病毒疫苗后的免疫反应（体液和细胞）。结果表明，接种疫苗可显著降低临床症状，且疫苗组的抗体水平（包括病毒中和（VN）抗体和免疫球蛋白G (IgG)）高于对照组。此外，疫苗显著增加了细胞因子的分泌，表明猫有th1型细胞免疫反应。此外，细胞免疫相关指标，如CD8+ T细胞、CD4+ T细胞和干扰素- γ水平，与接种猫FHV-1后的临床症状呈负相关，突出了其在保护猫免受FHV-1感染方面的重要作用。总之，本研究证明了细胞免疫反应在疫苗接种后保护猫免受FHV-1感染的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Frontiers in Veterinary Science Veterinary-General Veterinary

CiteScore

4.80

自引率

9.40%

发文量

1870

审稿时长

14 weeks

期刊介绍： Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy. Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field. Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.